ArticleScientific reports2019
Partially spatially coherent digital holographic microscopy and machine learning for quantitative analysis of human spermatozoa under oxidative stress condition.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Ascorbic acid mitigates oxidative structural degradation in bovine spermatozoa: a label-free quantitative phase microscopy study.Veterinary and animal science · 2026Article
- Digital Holographic Microscopy for Phenotypic Profiling of Adherent Cells.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Measurement of HbA1c with a new phase function using RBC phase image from a low-cost digital holographic microscopy.Biotechnology letters · 2025Article
- [Advances in the Application of Artificial Intelligence in the Field of Male Infertility].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Review
- Artificial Intelligence in IVF Laboratories: Elevating Outcomes Through Precision and Efficiency.Biology · 2024Review
- A narrative review of sperm selection technology for assisted reproduction techniques.Translational andrology and urology · 2024Review
- Label-free, high-throughput holographic imaging to evaluate mammalian gametes and embryos†.Biology of reproduction · 2024Review
- High space-time bandwidth product imaging in low coherence quantitative phase microscopy.Scientific reports · 2024Article
- Current Updates on Involvement of Artificial Intelligence and Machine Learning in Semen Analysis.Medicina (Kaunas, Lithuania) · 2024Review
- Roadmap on computational methods in optical imaging and holography [invited].Applied physics. B, Lasers and optics · 2024Review
- An Integrated Multi-Omics and Artificial Intelligence Framework for Advance Plant Phenotyping in Horticulture.Biology · 2023Review
- Label-free optical interferometric microscopy to characterize morphodynamics in living plants.Frontiers in plant science · 2023Review
- Highly sensitive quantitative phase microscopy and deep learning aided with whole genome sequencing for rapid detection of infection and antimicrobial resistance.Frontiers in microbiology · 2023Article
- Demystifying speckle field interference microscopy.Scientific reports · 2022Article
- CatSper and its CaM-like CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Lulworthinone: In Vitro Mode of Action Investigation of an Antibacterial Dimeric Naphthopyrone Isolated from a Marine Fungus.Marine drugs · 2022Article
- A Preliminary Study on the Evaluation of Human Sperm Head Morphology with a Domestic Digital Holographic Image System.Phenomics (Cham, Switzerland) · 2022Article
- Machine Learning Assisted Classification of Cell Lines and Cell States on Quantitative Phase Images.Cells · 2021Article
- High-throughput spatial sensitive quantitative phase microscopy using low spatial and high temporal coherent illumination.Scientific reports · 2021Article
- Machine learning for sperm selection.Nature reviews. Urology · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Semen quality assessed by sperm count and sperm cell characteristics such as morphology and motility, is considered to be the main determinant of men's reproductive health. Therefore, sperm cell selection is vital in assisted reproductive technology (ART) used for the treatment of infertility. Conventional bright field optical microscopy is widely utilized for the imaging and selection of sperm cells based on the qualitative analysis by experienced clinicians. In this study, we report the development of a highly sensitive quantitative phase microscopy (QPM) using partially spatially coherent light source, which is a label-free, non-invasive and high-resolution technique to quantify various biophysical parameters. The partial spatial coherence nature of light source provides a significant improvement in spatial phase sensitivity and hence reconstruction of the phase of the entire sperm cell is demonstrated, which was otherwise not possible using highly spatially coherent light source. High sensitivity of the system enables quantitative phase imaging of the specimens having very low refractive index contrast with respect to the medium like tail of the sperm cells. Further, it also benefits with accurate quantification of 3D-morphological parameters of sperm cells which might be helpful in the infertility treatment. The quantitative analysis of more than 2500 sperm cells under hydrogen peroxide (H
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.