ArticleNature communications2019
Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.
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Who cites it
124 citing papers in PubMed, 1 synthesis or guideline pooled it, 498 citations in OpenAlex.
- Molecular fluorophores for in vivo bioimaging in the second near-infrared window.European journal of nuclear medicine and molecular imaging · 2022Pooled it
- Ultrabright NIR-II fluorophores enabled by noncovalent conformational locking for in vivo inflammation imaging.Science advances · 2026Article
- High-Throughput Virtual Screening of Small Molecule Quenchers for Near-Infrared Fluorophores.Angewandte Chemie (International ed. in English) · 2026Article
- Microviscosity-gated excited-state partitioning in a NIR-II molecular rotor for disease imaging and imaging-guided photothermal therapy.Materials today. Bio · 2026Article
- Article
- Color-Pure Organic Luminophores: Characteristics, Definitions, Physical Basis and Fundamental Design Principles.Angewandte Chemie (International ed. in English) · 2026Review
- Silicon Flavylium Polymethine Dyes for Shortwave Infrared Imaging.Journal of the American Chemical Society · 2026Article
- pH-Responsive Materials for Therapy and Precision Biomedical Imaging.Chemical & biomedical imaging · 2026Review
- In vivo ultrasound-induced luminescence imaging via trianthracene derivatives nanomaterials.Nature protocols · 2026Review
- Structure-Property Relationships of Near-Infrared Cyanine Dyes: Chalcogen-Driven Singlet Oxygen Generation with High Fluorescence Efficiency.ACS omega · 2026Article
- Delineating precise surgical resection areas: recent advances in NIR-II fluorescence imaging molecular probes.Frontiers in oncology · 2026Review
- Advances in Second Near-Infrared Window Photothermal Agents and Photothermal Therapy for Tumors in Interdisciplinary Medical Research.Pharmaceutics · 2025Review
- Rapid discovery of drug-introduced multiple organ dysfunctionActa pharmaceutica Sinica. B · 2025Article
- A modular artificial intelligence framework to facilitate fluorophore design.Nature communications · 2025Article
- Mitochondrial Electron Flow Dynamics Imaging for Assessing Mitochondrial Quality and Drug Screening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Aggregation control of anionic pentamethine cyanine enabling excitation wavelength selective NIR-II fluorescence imaging-guided photodynamic therapy.Nature communications · 2025Article
- Enabling Visible Light Sensitization of YbAngewandte Chemie (International ed. in English) · 2025Article
- NIR-II-excited off-on-off fluorescent nanoprobes for sensitive molecular imaging in vivo.Nature communications · 2025Article
- Nanomaterial-assisted pancreatic cancer theranostics.Regenerative biomaterials · 2025Review
- Recent Advances in Indocyanine Green-Based Probes for Second Near-Infrared Fluorescence Imaging and Therapy.Research (Washington, D.C.) · 2025Review
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The contrast and sensitivity of in vivo fluorescence imaging has been revolutionized by molecular fluorophores operating in the second near-infrared window (NIR-II; 1000-1700 nm), but an ongoing challenge is the solvatochromism-caused quenching in aqueous solution for the long-wavelength absorbing fluorophores. Herein, we develop a series of anti-quenching pentamethine cyanine fluorophores that significantly overcome the severe solvatochromism, thus affording stable absorption/emission beyond 1000 nm with up to ~ 44-fold enhanced brightness and superior photostability in aqueous solution. These advantages allow for deep optical penetration (8 mm) as well as high-contrast and highly-stable lymphatic imaging superior to clinical-approved indocyanine green. Additionally, these fluorophores exhibit pH-responsive fluorescence, allowing for noninvasive ratiometric fluorescence imaging and quantification of gastric pH in vivo. The results demonstrate reliable accuracy in tissue as deep as 4 mm, comparable to standard pH electrode method. This work unlocks the potential of anti-quenching pentamethine cyanines for NIR-II biological applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.