Evidence map›Paper›PMID 30837344›Full record

ArticlemBio2019

Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes.

Jeremy Weaver, Fuad Mohammad, Allen R Buskirk, Gisela Storz

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 209 citations in OpenAlex.

  1. Approaches for Studying Context Specificity of Translation Inhibitor Action.International journal of molecular sciences · 2026
    Review
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  15. Analysis of stress-induced small proteins inbioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Review
  18. Cellular function of the GndA microprotein during heat shock.bioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Article

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jeremy WeaverDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Fuad MohammadDepartment of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Allen R BuskirkDepartment of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA buskirk@jhmi.edu storzg@mail.nih.gov.
Gisela StorzDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA buskirk@jhmi.edu storzg@mail.nih.gov.ORCID 0000-0001-6698-1241
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USJohns Hopkins University · US

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Small Regulatory ProteinsZIAHD008855 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STORZ, GISELA · 2009 to 2025
$16.3M
Interactions Regulating Translation and Protein Biogenesis in VivoU54GM105816 · NIGMS · UNIVERSITY OF NOTRE DAME · PI BUSKIRK, ALLEN ROWDON, CLARK, PATRICIA LOUISE · 2013 to 2017
$3.7M
The Mechanism of Pausing and Restarting Translation in BacteriaR01GM110113 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BUSKIRK, ALLEN ROWDON · 2014 to 2017
$1.2M
Small ORFsZ01HD008855 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STORZ, GISELA · 2008 to 2008
$516k
Intramural NIH HHS Z01 HD008855Intramural NIH HHS ZIA HD008855NIGMS NIH HHS R01 GM110113NIGMS NIH HHS T32 GM007445NIGMS NIH HHS U54 GM105816
6 · The paper itself

Abstract

Small proteins consisting of 50 or fewer amino acids have been identified as regulators of larger proteins in bacteria and eukaryotes. Despite the importance of these molecules, the total number of small proteins remains unknown because conventional annotation pipelines usually exclude small open reading frames (smORFs). We previously identified several dozen small proteins in the model organism

Indexed as

Peptide Chain Initiation, TranslationalEscherichia coliOligonucleotidesRibosomesRNA, MessengerSequence Analysis, DNAOligonucleotidesRNA, Messengeralternate ORFsantisensegenome annotationleader peptideRibo-seqsmall protein

Identifiers

PMID30837344
PMCPMC6401488
OpenAlexW2949435868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.