ArticlemBio2019
Changes in Intrinsic Antibiotic Susceptibility during a Long-Term Evolution Experiment with Escherichia coli.
Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Effects of florfenicol on linezolid resistance in Enterococcus faecium from waterfowl farms.Poultry science · 2026Article
- Environment-dependent epistasis shapes adaptation to fluctuating resources.bioRxiv : the preprint server for biology · 2026Article
- Antibiotic susceptibility ofmSphere · 2026Article
- Silver Nanoparticle-Antibiotic Combinations: A Strategy to Overcome Bacterial Resistance inAntibiotics (Basel, Switzerland) · 2025Article
- Genome and transcriptomic analysis of the adaptation ofComputational and structural biotechnology journal · 2024Review
- Impressive pan-genomic diversity ofiScience · 2024Article
- Electroacoustic Biosensor Systems for Evaluating Antibiotic Action on Microbial Cells.Sensors (Basel, Switzerland) · 2023Review
- The Effects of Preservatives on Antibiotic- and Preservative-Resistant Microbes and Nitrogen/Sulfur Cycle Associated Microbial Communities in Freshwater River Sediments.Antibiotics (Basel, Switzerland) · 2023Article
- Pervasive Selection for Clinically Relevant Resistance and Media Adaptive Mutations at Very Low Antibiotic Concentrations.Molecular biology and evolution · 2023Article
- Adaptation in Outbred Sexual Yeast is Repeatable, Polygenic and Favors Rare Haplotypes.Molecular biology and evolution · 2022Article
- Evolutionary History and Strength of Selection Determine the Rate of Antibiotic Resistance Adaptation.Molecular biology and evolution · 2022Article
- Evolution of Bacterial Persistence to Antibiotics during a 50,000-Generation Experiment in an Antibiotic-Free Environment.Antibiotics (Basel, Switzerland) · 2022Article
- Influence of Sub-Inhibitory Dosage of Cefotaxime on Multidrug ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Market forces determine the distribution of a leaky function in a simple microbial community.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Differentiation of Closely Related Oak-Associated Gram-Negative Bacteria by Label-Free Surface Enhanced Raman Spectroscopy (SERS).Microorganisms · 2021Article
- Genomic evolution of antibiotic resistance is contingent on genetic background following a long-term experiment withProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli.Molecular biology and evolution · 2020Article
- Using Selection by Nonantibiotic Stressors to Sensitize Bacteria to Antibiotics.Molecular biology and evolution · 2020Article
- Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators.Frontiers in bioengineering and biotechnology · 2020Review
- Historical contingency in the evolution of antibiotic resistance after decades of relaxed selection.PLoS biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-level resistance often evolves when populations of bacteria are exposed to antibiotics, by either mutations or horizontally acquired genes. There is also variation in the intrinsic resistance levels of different bacterial strains and species that is not associated with any known history of exposure. In many cases, evolved resistance is costly to the bacteria, such that resistant types have lower fitness than their progenitors in the absence of antibiotics. Some longer-term studies have shown that bacteria often evolve compensatory changes that overcome these tradeoffs, but even those studies have typically lasted only a few hundred generations. In this study, we examine changes in the susceptibilities of 12 populations of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.