Evidence map›Paper›PMID 30837333›Full record

ArticlemBio2019

Quorum Sensing Signal Selectivity and the Potential for Interspecies Cross Talk.

Samantha Wellington, E Peter Greenberg

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 135 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Frontiers in microbiology · 2026
    Article
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  7. Article
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  18. Silyl-Lipid FunctionalizedACS chemical biology · 2025
    Article
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Samantha WellingtonDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
E Peter GreenbergDepartment of Microbiology, University of Washington, Seattle, Washington, USA epgreen@uw.edu.ORCID 0000-0001-9474-8041
University of Washington · US

Funding

RESPIRATORY RESEARCH TRAINING PROGRAMT32HL007287 · NHLBI · UNIVERSITY OF WASHINGTON · PI Kristina Anne Crothers, David J. Horne · 1985 to 2026
$16.7M
QUORUM SENSING IN PSEUDOMONAS AERUGINOSAR01GM059026 · NIGMS · UNIVERSITY OF WASHINGTON · PI GREENBERG, EVERETT P · 1999 to 2019
$6.5M
NHLBI NIH HHS T32 HL007287NIGMS NIH HHS R01 GM059026
6 · The paper itself

Abstract

Many species of proteobacteria communicate with kin and coordinate group behaviors through a form of cell-cell signaling called acyl-homoserine lactone (AHL) quorum sensing (QS). Most AHL receptors are thought to be specific for their cognate signal, ensuring that bacteria cooperate and share resources only with closely related kin cells. Although specificity is considered fundamental to QS, there are reports of "promiscuous" receptors that respond broadly to nonself signals. These promiscuous responses expand the function of QS systems to include interspecies interactions and have been implicated in both interspecies competition and cooperation. Because bacteria are frequently members of polymicrobial communities, AHL cross talk between species could have profound impacts. To better understand the prevalence of QS promiscuity, we measured the activity of seven QS receptors in their native host organisms. To facilitate comparison of our results to previous studies, we also measured receptor activity using heterologous expression in

Indexed as

Microbial InteractionsQuorum SensingAcyl-ButyrolactonesGene Expression Regulation, BacterialProteobacteriaAcyl-Butyrolactonesacyl-homoserine lactonebacterial communicationgene regulationtranscription factors

Identifiers

PMID30837333
PMCPMC6401477
OpenAlexW2919390330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.