Evidence map›Paper›PMID 30837269›Full record

ArticleThe Journal of biological chemistry2019

Global biochemical and structural analysis of the type IV pilus from the Gram-positive bacterium

Jamie-Lee Berry, Ishwori Gurung, Jan Haug Anonsen, Ingrid Spielman, Elliot Harper, Alexander M J Hall, Vivianne J Goosens, Claire Raynaud, Michael Koomey, Nicolas Biais and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Functional Analysis of the Major Pilin Proteins of Type IV Pili inInternational journal of molecular sciences · 2024
    Article
  3. Tight-packing of large pilin subunits provides distinct structural and mechanical properties for theProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Characterization of a glycan-binding complex of minor pilins completes the analysis ofProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Article
  11. Landmark Discoveries and Recent Advances in Type IV Pilus Research.Microbiology and molecular biology reviews : MMBR · 2022
    Review
  12. Article
  13. Article
  14. The dental plaque biofilm matrix.Periodontology 2000 · 2021
    Review
  15. PilB fromProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Jamie-Lee BerryFrom the Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom.
Ishwori GurungFrom the Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom.
Jan Haug Anonsenthe Department of Biological Sciences, Proteomics and Mass Spectrometry Unit, University of Oslo, 0371 Oslo, Norway.
Ingrid Spielmanthe Department of Biology, Brooklyn College of the City University of New York, New York, New York 11210.
Elliot HarperFrom the Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom.
Alexander M J HallFrom the Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom.
Vivianne J GoosensFrom the Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom.
Claire RaynaudFrom the Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0002-7121-8424
Michael Koomeythe Department of Biological Sciences, Center for Integrative Microbial Evolution, University of Oslo, 0371 Oslo, Norway.
Nicolas Biaisthe Department of Biology, Brooklyn College of the City University of New York, New York, New York 11210.
Steve Matthewsthe Centre for Structural Biology, Imperial College London, London SW7 2AZ, United Kingdom.
Vladimir PelicicFrom the Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom, v.pelicic@imperial.ac.uk.ORCID 0000-0002-9456-4995
Imperial College London · GBThe Graduate Center, CUNY · USUniversity of Oslo · NOInstitute of Structural and Molecular Biology · GB

Funding

Mechanobiology of Neisseria MicrocoloniesSC2AI116566 · NIAID · BROOKLYN COLLEGE · PI BIAIS, NICOLAS · 2014 to 2016
$471k
Medical Research Council MR/L008408/1Medical Research Council MR/P022197/1NIAID NIH HHS SC2 AI116566
6 · The paper itself

Abstract

Type IV pili (Tfp) are functionally versatile filaments, widespread in prokaryotes, that belong to a large class of filamentous nanomachines known as type IV filaments (Tff). Although Tfp have been extensively studied in several Gram-negative pathogens where they function as key virulence factors, many aspects of their biology remain poorly understood. Here, we performed a global biochemical and structural analysis of Tfp in a recently emerged Gram-positive model,

Indexed as

BiopolymersFimbriae, BacterialFimbriae ProteinsMethylationProtein ConformationStreptococcusBiopolymersFimbriae ProteinsGram-positive bacteriamolecular motorpilinprotein structureStreptococcus sanguinistwitching motilitytype IV filamentstype IV pilivirulence factor

Identifiers

PMID30837269
PMCPMC6497953
OpenAlexW2919628835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.