Cytomegalovirus infection with pulmonary embolism, splenic vein thrombosis and monoclonal gammopathy of undetermined significance: a case and systematic review.

Esther de Rooij, Rolf Verheul, Mariëlle de Vreede, Ype de Jong

Abstract readCase ReportsSystematic Review

In one paragraph

Synthesis in BMJ case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Esther de RooijDepartment of Internal Medicine, Haaglanden Medical Center, Den Haag, The Netherlands.ORCID http://orcid.org/0000-0003-3017-2885

Rolf VerheulDepartment of Clinical Chemistry and Laboratory Medicine, LabWest, Haaglanden Medical Center, Den Haag, The Netherlands.

Mariëlle de VreedeDepartment of Haematology, Haaglanden Medical Center, Den Haag, The Netherlands.

Ype de JongDepartment of Internal Medicine, Haaglanden Medical Center, Den Haag, The Netherlands.ORCID http://orcid.org/0000-0002-7805-1508

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 62-year-old immunocompetent woman was admitted with cytomegalovirus (CMV) infection, pulmonary embolism, splenic vein thrombosis and monoclonal gammopathy of undetermined significance (MGUS). Anticoagulation therapy was started. Two months later, seroconversion of CMV IgM to IgG was observed, while the monoclonal protein was no longer detectable. This suggests a relationship between acute CMV infection, transient MGUS and thrombosis. In accordance with current best practice guidelines for provoked venous thromboembolism (VTE), anticoagulation therapy could be discontinued after 3 months instead of 6 for unprovoked VTE, thereby reducing unnecessary time at risk of bleeding complications. While the relationships between CMV and both MGUS and thrombosis have been described independently, we are first to describe these three conditions occurring simultaneously.Furthermore, we provide a systematic review on the relation between CMV, MGUS and thrombosis.

Indexed as

AnticoagulantsCytomegalovirus InfectionsFemaleHumansMiddle AgedMonoclonal Gammopathy of Undetermined SignificancePulmonary EmbolismSplenic VeinTreatment OutcomeVenous ThrombosisAnticoagulantshaematology (Incl blood transfusion)hepatitis othermalignant and benign haematologyportal veinvenous thromboembolism

Identifiers

PMID30837233

DOI10.1136/bcr-2018-226448

PMCPMC6424189

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.