ArticleBMC ecology2019
Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon.
Article in BMC ecology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Research Progress on the Major Histocompatibility Complex in Herbivores: Structure, Genetics, and Disease Resistance.Biology · 2026Review
- Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing.BMC genomics · 2024Article
- Article
- Coinfection patterns of two marine apicomplexans are not associated with genetic diversity of their polychaete host.The Journal of eukaryotic microbiology · 2023Article
- Genomic heterozygosity is associated with parasite abundance, but the effects are not mediated by host condition.Evolutionary ecology · 2023Article
- Spatio-temporal analyses reveal infectious disease-driven selection in a free-ranging ungulate.Royal Society open science · 2021Article
- Reproductive females and young mouflon (Parasitology · 2021Article
- Host Genetic Diversity and Infectious Diseases. Focus on Wild Boar, Red Deer and Tuberculosis.Animals : an open access journal from MDPI · 2021Review
- Does host socio-spatial behavior lead to a fine-scale spatial genetic structure in its associated parasites?Parasite (Paris, France) · 2019Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParasite infections can have substantial impacts on population dynamics and are accordingly a key challenge for wild population management. Here we studied genetic mechanisms driving parasite resistance in a large herbivore through a comprehensive approach combining measurements of neutral (16 microsatellites) and adaptive (MHC DRB1 exon 2) genetic diversity and two types of gastrointestinal parasites (nematodes and coccidia).
resultsWhile accounting for other extrinsic and intrinsic predictors known to impact parasite load, we show that both neutral genetic diversity and DRB1 are associated with resistance to gastrointestinal nematodes. Intermediate levels of multi-locus heterozygosity maximized nematodes resistance, suggesting that both in- and outbreeding depression might occur in the population. DRB1 heterozygosity and specific alleles effects were detected, suggesting the occurrence of heterozygote advantage, rare-allele effects and/or fluctuating selection. On the contrary, no association was detected between genetic diversity and resistance to coccidia, indicating that different parasite classes are impacted by different genetic drivers.
conclusionsThis study provides important insights for large herbivores and wild sheep pathogen management, and in particular suggests that factors likely to impact genetic diversity and allelic frequencies, including global changes, are also expected to impact parasite resistance.
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Registered trials
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