ArticleBMC genomics2019
High-resolution population structure and runs of homozygosity reveal the genetic architecture of complex traits in the Lipizzan horse.
Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 78 citations in OpenAlex.
- Characterization of Lipizzan Horse Population From Lipica Stud Using Molecular and Pedigree Data.Animal genetics · 2026Article
- An increased number of heterozygous calls in the AxiomTM Equine Genotyping Array.G3 (Bethesda, Md.) · 2026Article
- Genetic Diversity and Population Structure in Seven Lipizzan Populations Based on Microsatellite Genotyping.Animals : an open access journal from MDPI · 2026Article
- Population Structure and Genetic Diversity Among Lipizzan Mare Families in Hungary Based on Microsatellite Genotyping.Animals : an open access journal from MDPI · 2026Article
- Comparing Genomic and Pedigree Inbreeding Coefficients in the Slovenian Lipizzan Horse as a Case Study for Small Closed Populations.Animals : an open access journal from MDPI · 2025Article
- Insights into Genomic Patterns of Homozygosity in the Endangered Dülmen Wild Horse Population.Genes · 2025Article
- Identification of candidate gene networks affecting the number of somatic cells count and milk production in Iranian Holstein cows using Genome-wide association study.Scientific reports · 2025Article
- Genomic Patterns of Homozygosity and Genetic Diversity in the Rhenish German Draught Horse.Genes · 2025Article
- Genetic diversity and signatures of selection in Icelandic horses and Exmoor ponies.BMC genomics · 2024Article
- Using high-density SNP data to unravel the origin of the Franches-Montagnes horse breed.Genetics, selection, evolution : GSE · 2024Article
- Genetic Diversity of KazakhstaniVeterinary sciences · 2023Article
- Article
- Identification of runs of homozygosity in Western honey bees (Ecology and evolution · 2023Article
- Unlocking Horse Y Chromosome Diversity.Genes · 2022Review
- Genetic Diversity and Selection Signatures in Jianchang Black Goats Revealed by Whole-Genome Sequencing Data.Animals : an open access journal from MDPI · 2022Article
- Genome-wide survey on three local horse populations with a focus on runs of homozygosity pattern.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2022Article
- Runs of homozygosity in Sable Island feral horses reveal the genomic consequences of inbreeding and divergence from domestic breeds.BMC genomics · 2022Article
- Genetic Diversity and Structure of the Main Danubian Horse Paternal Genealogical Lineages Based on Microsatellite Genotyping.Veterinary sciences · 2022Article
- Equine vitiligo-like depigmentation in grey horses is related to genes involved in immune response and tumor metastasis.BMC veterinary research · 2021Article
- Association of inbreeding and regional equine leucocyte antigen homozygosity with the prevalence of insect bite hypersensitivity in Old Kladruber horse.Animal genetics · 2021Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe sample ascertainment bias due to complex population structures remains a major challenge in genome-wide investigations of complex traits. In this study we derived the high-resolution population structure and levels of autozygosity of 377 Lipizzan horses originating from five different European stud farms utilizing the SNP genotype information of the high density 700 k Affymetrix Axiom™ Equine genotyping array. Scanning the genome for overlapping runs of homozygosity (ROH) shared by more than 50% of horses, we identified homozygous regions (ROH islands) in order to investigate the gene content of those candidate regions by gene ontology and enrichment analyses.
resultsThe high-resolution population network approach revealed well-defined substructures according to the origin of the horses (Austria, Slovakia, Croatia and Hungary). The highest mean genome coverage of ROH (S
conclusionsWe demonstrated that the assessment of high-resolution population structures within one single breed supports the downstream genetic analyses (e.g. the identification of ROH islands). By means of ROH island analyses, we identified the genes SPRY4, NDFIP1, IMPDH2, HSP90AB1, which might play an important role for further studies on equine melanoma. Furthermore, our results highlighted the impact of the homeobox-A and B cluster involved in morphogenesis of Lipizzan horses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.