ArticleJournal of the Royal Society, Interface2019
PEEK surface modification by fast ambient-temperature sulfonation for bone implant applications.
Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 112 citations in OpenAlex.
- Overcoming the Biomechanical Limitations of Titanium-Zirconia Dental Implants: Rationale for a Novel Ti-PEEK-Zr Tri-Layered Concept.Journal of functional biomaterials · 2026Review
- Process-Driven Optimization of FDM Porous PEEK Scaffolds for Alloplastic Bone Grafts.ACS omega · 2025Article
- Topography-based implants for bone regeneration: Design, biological mechanism, and therapeutics.Materials today. Bio · 2025Review
- Review
- Designing Superhydrophilic 3D Porous Surfaces on Polyetherketoneketone Surfaces to Promote Biocompatibility.Journal of functional biomaterials · 2025Article
- Regulation of immune microenvironments by polyetheretherketone surface topography for improving osseointegration.Journal of nanobiotechnology · 2025Article
- BCS II/IV antibiotics blended with SPEEK nanofibrous mat as an alternative for recurrent wound care: AnCurrent research in pharmacology and drug discovery · 2025Article
- Fabrication and X-ray microtomography of sandwich-structured PEEK implants for skull defect repair.Scientific reports · 2024Article
- The ability of SPEEK to promote the proliferation and osteogenic differentiation of BMSCs on PEEK surfaces.Heliyon · 2024Article
- An investigation of methods to enhance adhesion of conductive layer and dielectric substrate for additive manufacturing of electronics.Scientific reports · 2024Article
- Studying and Characterization of Coating of Zein-CaSiOInternational journal of dentistry · 2024Article
- Novel Carboxylation Method for Polyetheretherketone (PEEK) Surface Modification Using Friedel-Crafts Acylation.International journal of molecular sciences · 2023Article
- Enhancing PEEK surface bioactivity: Investigating the effects of combining sulfonation with sub-millimeter laser machining.Materials today. Bio · 2023Article
- Sulfonated Polyether Ketone Membranes Embedded with Nalidixic Acid-An Emerging Controlled Drug Releaser.Polymers · 2023Article
- Review
- Surface Treatments of PEEK for Osseointegration to Bone.Biomolecules · 2023Review
- Synergistic effect of sulfonation followed by precipitation of amorphous calcium phosphate on the bone-bonding strength of carbon fiber reinforced polyetheretherketone.Scientific reports · 2023Article
- Design of an Antibiotic-Releasing Polymer: Physicochemical Characterization and Drug Release Patterns.Membranes · 2023Article
- Surface modification of Polyether-ether-ketone for enhanced cell response: a chemical etching approach.Frontiers in bioengineering and biotechnology · 2023Article
- Biocompatibility and osteoinductive ability of casein phosphopeptide modified polyetheretherketone.Frontiers in bioengineering and biotechnology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We develop a simple, fast and economical surface treatment under ambient temperature to improve the hydrophilicity and osteoconductivity of polyetheretherketone (PEEK) for bone implant applications. A major challenge in bone implants is the drastic difference in stiffness between traditional implant materials (such as titanium and stainless steel) and human bone. PEEK is biocompatible with an elastic modulus closely matching that of human bone, making it a highly attractive alternative. However, its bio-inert and poorly hydrophilic surface presents a serious challenge for osseointegration. Sulfonation can improve hydrophilicity and introduce bioactive sulfonate groups, but PEEK sulfonation has traditionally been applied for fuel cells, employing elevated temperatures and long reaction times to re-cast PEEK into sulfonated films. Little research has systematically studied PEEK surface modification by short reaction time (seconds) and ambient-temperature sulfonation for biomedical applications. Here, we investigate three ambient-temperature sulfonation treatments under varying reaction times (5-90 s) and evaluate the hydrophilicity and morphology of 15 modified PEEK surfaces. We establish an optimal treatment using 30 s H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.