ArticleJournal of the Royal Society, Interface2019
Limits to the rate of information transmission through the MAPK pathway.
Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Quantifying cancer- and drug-induced changes in Shannon information capacity of RTK signaling.Scientific reports · 2025Article
- The MAPK/ERK channel capacity exceeds 6 bit/hour.PLoS computational biology · 2023Article
- Quantifying information of intracellular signaling: progress with machine learning.Reports on progress in physics. Physical Society (Great Britain) · 2022Review
- Universal antigen encoding of T cell activation from high-dimensional cytokine dynamics.Science (New York, N.Y.) · 2022Article
- Mapping the dynamic transfer functions of eukaryotic gene regulation.Cell systems · 2021Article
- Information transmission from NFkB signaling dynamics to gene expression.PLoS computational biology · 2020Article
- Modeling and measurement of signaling outcomes affecting decision making in noisy intracellular networks using machine learning methods.Integrative biology : quantitative biosciences from nano to macro · 2020Article
- Revealing hidden information in osteoblast's mechanotransduction through analysis of time patterns of critical events.BMC bioinformatics · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two important signalling pathways of NF-κB and ERK transmit merely 1 bit of information about the level of extracellular stimulation. It is thus unclear how such systems can coordinate complex cell responses to external cues. We analyse information transmission in the MAPK/ERK pathway that converts both constant and pulsatile EGF stimulation into pulses of ERK activity. Based on an experimentally verified computational model, we demonstrate that, when input consists of sequences of EGF pulses, transmitted information increases nearly linearly with time. Thus, pulse-interval transcoding allows more information to be relayed than the amplitude-amplitude transcoding considered previously for the ERK and NF-κB pathways. Moreover, the information channel capacity C, or simply bitrate, is not limited by the bandwidth B = 1/ τ, where τ ≈ 1 h is the relaxation time. Specifically, when the input is provided in the form of sequences of short binary EGF pulses separated by intervals that are multiples of τ/ n (but not shorter than τ), then for n = 2, C ≈ 1.39 bit h
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