ArticleBiology letters2019
'Meiotic genes' are constitutively expressed in an asexual amoeba and are not necessarily involved in sexual reproduction.
Article in Biology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 29 citations in OpenAlex.
- Repair and misrepair of telomeric DNA in dynamic interactions with PML nuclear bodies and lamin B1 in doxorubicin-treated cancer cells.Nucleus (Austin, Tex.) · 2026Article
- Diverse Genome Structures among Eukaryotes May Have Arisen in Response to Genetic Conflict.Genome biology and evolution · 2024Review
- Rethinking asexuality: the enigmatic case of functional sexual genes in Lepraria (Stereocaulaceae).BMC genomics · 2024Article
- HOP1 and HAP2 are conserved components of the meiosis-related machinery required for successful mating in Leishmania.Nature communications · 2023Article
- Omics of an Enigmatic Marine Amoeba Uncovers Unprecedented Gene Trafficking from Giant Viruses and Provides Insights into Its Complex Life Cycle.Microbiology research · 2023Article
- The Transcriptome and Proteome Networks of Malignant Tumours Reveal Atavistic Attractors of Polyploidy-Related Asexual Reproduction.International journal of molecular sciences · 2022Article
- Acanthamoeba castellanii exhibits intron retention during encystment.Parasitology research · 2022Article
- Analysis of Acanthamoeba genotypes from public freshwater sources in Thailand reveals a new genotype, T23 Acanthamoeba bangkokensis sp. nov.Scientific reports · 2021Article
- Reproduction in Trypanosomatids: Past and Present.Biology · 2021Review
- Divergent Gene Expression Following Duplication of Meiotic Genes in the Stick Insect Clitarchus hookeri.Genome biology and evolution · 2021Article
- Article
- 'Meiotic genes' are constitutively expressed in an asexual amoeba and are not necessarily involved in sexual reproduction.Biology letters · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The amoebae (and many other protists) have traditionally been considered as asexual organisms, but suspicion has been growing that these organisms are cryptically sexual or are at least related to sexual lineages. This contention is mainly based on genome studies in which the presence of 'meiotic genes' has been discovered. Using RNA-seq (next-generation shotgun sequencing, identifying and quantifying the RNA species in a sample), we have found that the entire repertoire of meiotic genes is expressed in exponentially growing Acanthamoeba and we argue that these so-called meiotic genes are involved in the related process of homologous recombination in this amoeba. We contend that they are only involved in meiosis in other organisms that indulge in sexual reproduction and that homologous recombination is important in asexual protists as a guard against the accumulation of mutations. We also suggest that asexual reproduction is the ancestral state.
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