ArticleJournal of enzyme inhibition and medicinal chemistry2019
Synthesis and biological evaluation of ursolic acid derivatives bearing triazole moieties as potential anti-Toxoplasma gondii agents.
Article in Journal of enzyme inhibition and medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The Search for Drugs Derived from Natural Products forCurrent topics in medicinal chemistry · 2024Pooled it
- 1,3-Dipolar Cycloaddition and Mannich Reactions of Alkynyl Triterpenes: New Trends in Synthetic Strategies and Pharmacological Applications.International journal of molecular sciences · 2025Review
- Ursolic acid in colorectal cancer: mechanisms, current status, challenges, and future research directions.Pharmacological reports : PR · 2025Review
- The Intestinal Barrier Protective Effect of Indole Aldehyde Derivatives on AcuteMolecules (Basel, Switzerland) · 2024Article
- Synthesis of Ursolic Acid-based Hybrids:Recent advances in anti-infective drug discovery · 2024Article
- Ursolic acid: biological functions and application in animal husbandry.Frontiers in veterinary science · 2023Review
- Synthesis and evaluation of anticancer activity of quillaic acid derivatives: A cell cycle arrest and apoptosis inducer through NF-Frontiers in chemistry · 2022Article
- Anti-Toxoplasma gondii effect of lupane-type triterpenes from the bark of black alder (Alnus glutinosa) and identification of a potential target by reverse docking.Parasite (Paris, France) · 2022Article
- Application of triazoles in the structural modification of natural products.Journal of enzyme inhibition and medicinal chemistry · 2021Review
- In vitro anti-Toxoplasma gondii efficacy of synthesised benzyltriazole derivatives.The Onderstepoort journal of veterinary research · 2021Article
- Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo.The Korean journal of parasitology · 2021Article
- Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic MetabolismFrontiers in oncology · 2021Article
- Novel acyl carbamates and acyl / diacyl ureas show in vitro efficacy against Toxoplasma gondii and Cryptosporidium parvum.International journal for parasitology. Drugs and drug resistance · 2020Article
- Urolithin-A attenuates neurotoxoplasmosis and alters innate response towards predator odor.Brain, behavior, & immunity - health · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ursolic acid (UA), a plant-derived compound, has many properties beneficial to health. In the present study, we synthesised three series of novel UA derivatives and evaluated their anti-Toxoplasma gondii activity both in vitro and in vivo. Most derivatives exhibited an improved anti-T. gondii activity in vitro when compared with UA (parent compound), whereas compound 3d exhibited the most potent anti-T. gondii activity in vivo. Spiramycin served as the positive control. Additionally, determination of biochemical parameters, including the liver and spleen indexes, indicated compound 3d to effectively reduce hepatotoxicity and significantly enhance anti-oxidative effects, as compared with UA. Furthermore, our molecular docking study indicated compound 3d to possess a strong binding affinity for T. gondii calcium-dependent protein kinase 1 (TgCDPK1). Based on these findings, we conclude that compound 3d, a derivative of UA, could act as a potential inhibitor of TgCDPK1.
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Registered trials
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