Evidence map›Paper›PMID 30836718›Full record

ReviewMolecules (Basel, Switzerland)2019

Dietary Phytochemicals Targeting Cancer Stem Cells.

Alena Liskova, Peter Kubatka, Marek Samec, Pavol Zubor, Milos Mlyncek, Tibor Bielik, Samson Mathews Samuel, Anthony Zulli, Taeg Kyu Kwon, Dietrich Büsselberg

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  7. Anti‑proliferative effects ofOncology letters · 2025
    Article
  8. Review
  9. Review
  10. Chemopreventive and therapeutic effects ofFrontiers in pharmacology · 2025
    Article
  11. Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals.Bioengineering (Basel, Switzerland) · 2024
    Review
  12. Review
  13. Frontiers in pharmacology · 2024
    Article
  14. Frontiers in oncology · 2024
    Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alena LiskovaClinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, 03601 Bratislava, Slovakia. alenka.liskova@gmail.com.
Peter KubatkaDepartment of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, 03601 Bratislava, Slovakia. kubatka@jfmed.uniba.sk.
Marek SamecClinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, 03601 Bratislava, Slovakia. marek.samec@gmail.com.
Pavol ZuborClinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, 03601 Bratislava, Slovakia. Pavol.Zubor@jfmed.uniba.sk.
Milos MlyncekDepartment of Obstetrics and Gynecology Faculty Hospital Nitra Constantine the Philosopher University, 949 01 Nitra, Slovakia. mlyncekmilos@hotmail.com.
Tibor BielikClinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, 03601 Bratislava, Slovakia. tbielik57@gmail.com.
Samson Mathews SamuelDepartment of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha 24144, Qatar. sms2016@qatar-med.cornell.edu.
Anthony ZulliInstitute for Health and Sport, Victoria University, Melbourne, VIC 3011, Australia. Anthony.Zulli@vu.edu.au.
Taeg Kyu KwonDepartment of Immunology and School of Medicine, Keimyung University, Dalseo-Gu, Daegu 426 01, Korea. kwontk@dsmc.or.kr.
Dietrich BüsselbergDepartment of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha 24144, Qatar. dib2015@qatar-med.cornell.edu.

Funding

Agentúra na Podporu Výskumu a Vývoja APVV-16-0021Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky VEGA 1/0136/19, VEGA 1/0018/16
6 · The paper itself

Abstract

There is an increasing awareness of the importance of a diet rich in fruits and vegetables for human health. Cancer stem cells (CSCs) are characterized as a subpopulation of cancer cells with aberrant regulation of self-renewal, proliferation or apoptosis leading to cancer progression, invasiveness, metastasis formation, and therapy resistance. Anticancer effects of phytochemicals are also directed to target CSCs. Here we provide a comprehensive review of dietary phytochemicals targeting CSCs. Moreover, we evaluate and summarize studies dealing with effects of dietary phytochemicals on CSCs of various malignancies in preclinical and clinical research. Dietary phytochemicals have a significant impact on CSCs which may be applied in cancer prevention and treatment. However, anticancer effects of plant derived compounds have not yet been fully investigated in clinical research.

Indexed as

ApoptosisCell ProliferationEatingFruitHumansNeoplasmsNeoplastic Stem CellsPhytochemicalsSignal TransductionVegetablesPhytochemicalscancer stem cellscell signalingfruitphytochemicalsplant-derived foodsvegetable

Identifiers

PMID30836718
PMCPMC6429493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.