Evidence map›Paper›PMID 30836674›Full record

ReviewBiosensors2019

Electrochemical Biosensors as Potential Diagnostic Devices for Autoimmune Diseases.

Anca Florea, Gheorghe Melinte, Ioan Simon, Cecilia Cristea

Open access · goldAbstract readReview
In one paragraph

Review in Biosensors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anca FloreaAnalytical Chemistry Department, Iuliu Haţieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. florea.ancas@yahoo.com.
Gheorghe MelinteAnalytical Chemistry Department, Iuliu Haţieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. Melinte.Gheorghe@umfcluj.ro.
Ioan SimonDepartment of Surgery IV, CFR Hospital, Iuliu Haţieganu University of Medicine and Pharmacy, 18 Republicii St, 400015 Cluj-Napoca, Romania. isimon@umfcluj.ro.
Cecilia CristeaAnalytical Chemistry Department, Iuliu Haţieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. ccristea@umfcluj.ro.ORCID 0000-0002-4158-3324
Iuliu Hațieganu University of Medicine and Pharmacy · RO

Funding

Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii PN-III-P1-1.2-PCCDI2017-0221
6 · The paper itself

Abstract

An important class of biosensors is immunosensors, affinity biosensors that are based on the specific interaction between antibodies and antigens. They are classified in four classes based on the type of employed transducer: electrochemical, optical, microgravimetric, and thermometric and depending on the type of recognition elements, antibodies, aptamers, microRNAs and recently peptides are integrating parts. Those analytical devices are able to detect peptides, antibodies and proteins in various sample matrices, without many steps of sample pretreatment. Their high sensitivity, low cost and the easy integration in point of care devices assuring portability are attracting features that justify the increasing interest in their development. The use of nanomaterials, simultaneous multianalyte detection and integration on platforms to form point-of-care devices are promising tools that can be used in clinical analysis for early diagnosis and therapy monitoring in several pathologies. Taking into account the growing incidence of autoimmune disease and the importance of early diagnosis, electrochemical biosensors could represent a viable alternative to currently used diagnosis methods. Some relevant examples of electrochemical assays for autoimmune disease diagnosis developed in the last several years based on antigens, antibodies and peptides as receptors were gathered and will be discussed further.

Indexed as

Autoimmune DiseasesBiosensing TechniquesEarly DiagnosisElectrochemical TechniquesHumansNanostructuresautoimmune diseasesbiomarkersimmunosensors

Identifiers

PMID30836674
PMCPMC6468465
OpenAlexW2918438621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.