ReviewInternational journal of molecular sciences2019
Sample Delivery Media for Serial Crystallography.
Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Polyethylene Terephthalate Film-Based Sample Holder for Fixed-Target Serial Femtosecond Crystallography.Materials (Basel, Switzerland) · 2026Article
- Sample delivery methods for protein X-ray crystallography with a special focus on sample consumption.Nature communications · 2025Review
- Effect of crystal-to-detector distance shift on data processing in serial crystallography.PloS one · 2025Article
- Data of serial synchrotron crystallography of xylanase GH11 fromData in brief · 2024Article
- Guide to serial synchrotron crystallography.Current research in structural biology · 2024Review
- A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers.Nature communications · 2023Article
- All polymer microfluidic chips-A fixed target sample delivery workhorse for serial crystallography.Biomicrofluidics · 2023Article
- Molecular Dynamics-From Macromolecule to Small Molecules.International journal of molecular sciences · 2022Article
- Beef tallow injection matrix for serial crystallography.Scientific reports · 2022Article
- Hit and Indexing Rate in Serial Crystallography: Incomparable Statistics.Frontiers in molecular biosciences · 2022Article
- Polyimide mesh-based sample holder with irregular crystal mounting holes for fixed-target serial crystallography.Scientific reports · 2021Article
- Room-Temperature Structure of Xylitol-Bound Glucose Isomerase by Serial Crystallography: Xylitol Binding in the M1 Site Induces Release of Metal Bound in the M2 Site.International journal of molecular sciences · 2021Article
- Molecular Dynamics-From Small Molecules to Macromolecules.International journal of molecular sciences · 2021Article
- Lard Injection Matrix for Serial Crystallography.International journal of molecular sciences · 2020Article
- Polysaccharide-Based Injection Matrix for Serial Crystallography.International journal of molecular sciences · 2020Article
- Shortening injection matrix for serial crystallography.Scientific reports · 2020Article
- The XFEL Protein Crystallography: Developments and Perspectives.International journal of molecular sciences · 2019Article
- Nylon mesh-based sample holder for fixed-target serial femtosecond crystallography.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
X-ray crystallographic methods can be used to visualize macromolecules at high resolution. This provides an understanding of molecular mechanisms and an insight into drug development and rational engineering of enzymes used in the industry. Although conventional synchrotron-based X-ray crystallography remains a powerful tool for understanding molecular function, it has experimental limitations, including radiation damage, cryogenic temperature, and static structural information. Serial femtosecond crystallography (SFX) using X-ray free electron laser (XFEL) and serial millisecond crystallography (SMX) using synchrotron X-ray have recently gained attention as research methods for visualizing macromolecules at room temperature without causing or reducing radiation damage, respectively. These techniques provide more biologically relevant structures than traditional X-ray crystallography at cryogenic temperatures using a single crystal. Serial femtosecond crystallography techniques visualize the dynamics of macromolecules through time-resolved experiments. In serial crystallography (SX), one of the most important aspects is the delivery of crystal samples efficiently, reliably, and continuously to an X-ray interaction point. A viscous delivery medium, such as a carrier matrix, dramatically reduces sample consumption, contributing to the success of SX experiments. This review discusses the preparation and criteria for the selection and development of a sample delivery medium and its application for SX.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.