ArticleNeonatology2019
Long-Term Neurodevelopmental and Functional Outcomes of Infants Born Very Preterm and/or with a Very Low Birth Weight.
Article in Neonatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Cerebral oxygenation during immediate fetal-to-neonatal transition and fidgety movements between six to 20 weeks of corrected age: An ancillary study to the COSGOD III trial.European journal of pediatrics · 2024Trial
- Late childhood and adolescent health outcomes in preterm-born infants during 2004-2012: a population-based cohort study in British Columbia, Canada.Lancet regional health. Americas · 2026Article
- Habenula volume alterations in adults born very preterm.Scientific reports · 2026Article
- Cerebral Oxygenation during the First 15 Minutes after Birth and Short-Term Outcome Measured by the Motor Optimality Score-Revised in Preterm Infants.Neonatology · 2026Article
- Subclinical but significant: A multi-informant comparative study on early socio-emotional difficulties in preterm preschoolers.Child and adolescent psychiatry and mental health · 2026Article
- Exposure to enriched environment and parental care ameliorates brain pathology and behavioral impairment after germinal-matrix intraventricular hemorrhage.Molecular psychiatry · 2026Article
- Implementation of developmental care in routine NICU practice and early clinical outcomes in preterm infants.Frontiers in pediatrics · 2026Article
- The impact of very preterm vs very low birth weight on early and mid-adulthood preference-based HRQoL outcomes: findings from the Dutch study on preterm and small for gestational age infants.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Perinatal risk factors for young adults to be not engaged in employment, education or training (NEET) and its mediators: longitudinal analysis of the QLSCD cohort study.Social psychiatry and psychiatric epidemiology · 2025Article
- Neonatal multimorbidity and the phenotype of premature aging in preterm infants.Pediatric research · 2025Review
- Long-term health outcomes of preterm birth: a narrative review.Frontiers in pediatrics · 2025Review
- Complications of Preterm Birth-The Importance of Care for the Outcome: A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- Intellectual Development in Mexican Preterm Children at Risk of Perinatal Brain Damage: A Longitudinal Study.Children (Basel, Switzerland) · 2024Article
- The relationship between neonatal stress in preterm infants and developmental outcomes at the corrected age of 24-30 months.Frontiers in psychology · 2024Article
- Psychometric Performance of Generic Childhood Multi-Attribute Utility Instruments in Preterm and Low Birthweight Populations: A Systematic Review.Children (Basel, Switzerland) · 2023Review
- Impact of early-onset fetal growth restriction on the neurodevelopmental outcome of very preterm infants at 24 months: a retrospective cohort study.BMC pediatrics · 2023Article
- Pregnancy, delivery and neonatal complications in women with schizophrenia: a national population-based cohort study.The Lancet regional health. Europe · 2021Article
- Identifying the Critical Threshold for Long-Term Pediatric Neurological Hospitalizations of the Offspring in Preterm Delivery.Journal of clinical medicine · 2021Article
- Multivariate Patterns of Brain-Behavior-Environment Associations in the Adolescent Brain and Cognitive Development Study.Biological psychiatry · 2021Article
- Germinal Matrix-Intraventricular Hemorrhage of the Preterm Newborn and Preclinical Models: Inflammatory Considerations.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBirth weight (BW) is often used as a proxy for gestational age (GA) in studies on preterm birth. Recent findings indicate that, in addition to perinatal outcomes, subjects born very preterm (VP; GA < 32 weeks) differ from those with a very low birth weight (VLBW; BW < 1,500 g) in postnatal growth up to their final height.
objectiveTo study whether neurodevelopmental and functional outcomes at the age of 19 years differ in VP and/or VLBW subjects.
methods705 19-year-old subjects from the Project on Preterm and Small-for-Gestational-Age Infants (POPS) cohort were classified as (1) VP+/VLBW+ (n = 354), (2) VP+/VLBW- (n = 144), or (3) VP-/VLBW+ (n = 207), and compared with regard to IQ as assessed with the Multicultural Capacity Test-intermediate level; neuromotor function using Touwen's examination of mild neurologic dysfunction; hearing loss; self- and parent-reported behavioral and emotional functioning; educational achievement and occupation; and self-assessed health using the Health Utilities Index and the London Handicap Scale.
resultsVP+/VLBW- infants, on average, had 3.8-point higher IQ scores (95% confidence interval [CI] 0.5-7.1), a trend towards higher educational achievement, 3.3-dB better hearing (95% CI 1.2-5.4), and less anxious behavior, attention problems, and internalizing behavior than to VP+/VLBW+ subjects. VP-/VLBW+ infants reported 1.8 increased odds (95% CI 1.2-2.6) of poor health compared to VP+/VLBW+ subjects.
conclusionsAt the age of 19 years, subjects born VP+/VLBW+, VP+/VLBW-, and VP-/VLBW+ have different neurodevelopmental and functional outcomes, although effect sizes are small. Hence, the terms VP and VLBW are not interchangeable. We recommend, at least for industrialized countries, to base inclusion in future studies on preterm populations on GA instead of on BW.
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