ArticleGastroenterology2019
GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2.
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Article in Gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62 citing papers in PubMed, 89 citations in OpenAlex.
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- Identification of candidate microRNA biomarkers of endometriosis in different bodily fluids.Scientific reports · 2026Article
- USP25 attenuates the immunosuppressive tumor microenvironment via the deubiquitination of TAB2 in head and neck squamous cell carcinoma.Cell death discovery · 2025Article
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- miRNA-200a suppresses GNAI1 and PLCB4 to modulate skin pigmentation in cashmere goats.Scientific reports · 2025Article
- Unraveling the Complexities of Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease.International journal of molecular sciences · 2025Review
- Plasma Exosomal-Derived SERPINA1 and GNAI2 Downregulation as Potential Diagnostic Biomarkers of Kawasaki Disease with Coronary Artery Aneurysms.International journal of molecular sciences · 2025Article
- Main Genes Linked to the Immune Microenvironment in High-Grade Serous Ovarian Cancer.Advanced biomedical research · 2025Article
- Immunotherapy against colorectal cancer via delivery of anti-PD-L1 nanobody mRNA.eGastroenterology · 2025Article
- Neuroprotective and antimalarial effects ofFrontiers in veterinary science · 2025Article
- Exosomal miR-320d promotes angiogenesis and colorectal cancer metastasis via targeting GNAI1 to affect the JAK2/STAT3 signaling pathway.Cell death & disease · 2024Article
- Key Disease-Related Genes and Immune Cell Infiltration Landscape in Inflammatory Bowel Disease: A Bioinformatics Investigation.International journal of molecular sciences · 2024Article
- Step by step analysis on gene datasets of growth phases in hematopoietic stem cells.Biochemistry and biophysics reports · 2024Article
- Vitamin DCancers · 2024Article
- IL6ST: A Novel Therapeutic Target for Managing and Treating Colorectal Cancer Via Ferroptosis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Article
- Ameliorative Effect of Areca Nut Polyphenols on Adverse Effects Induced by Lipopolysaccharides in RAW264.7 Cells.Molecules (Basel, Switzerland) · 2024Article
- Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota.Cell & bioscience · 2023Review
- Role of Interleukins in Inflammation-Mediated Tumor Immune Microenvironment Modulation in Colorectal Cancer Pathogenesis.Digestive diseases and sciences · 2023Review
2 more citing papers are in PubMed but not listed here.
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Authors and funding
44 authors at 11 institutions in 3 countries.
Zhi-Wei LiCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Beicheng SunDepartment of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
Ting GongCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Sheng GuoCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; Department of Endocrine, Genetics and Metabolism, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Jianhua ZhangCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; Department of Pediatrics, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Junlong WangCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Atsushi SugawaraInstitute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.
Meisheng JiangDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, California.
Junjun YanDepartment of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Alexandra GuraryDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.
Xin ZhengCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Bifeng GaoDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Shu-Yuan XiaoDepartment of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China; Department of Pathology, University of Chicago, Chicago, Illinois.
Wenlian ChenEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Chi MaCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Christine FarrarThe Microscopy, Imaging, and Flow Cytometry Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii.
Chenjun ZhuCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Owen T M ChanPathology Core, University of Hawaii Cancer Center, Honolulu, Hawaii.
Can XinCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Andrew WinnickiCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
John WinnickiCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Mingxin TangCenter for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.
Ryan ParkCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Mary WinnickiCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Katrina DienerDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Zhanwei WangCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Qicai LiuCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; Department of Cardiology and Heart Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Catherine H ChuCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Zhaohui L ArterCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Peibin YueCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Lindsay AlpertDepartment of Pathology, University of Chicago, Chicago, Illinois.
George S HuiDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.
Peiwen FeiCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
James TurksonCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Wentian YangDepartment of Orthopedics, Rhode Island Hospital, Brown University Alpert Medical School, Providence, Rhode Island.
Guangyu WuDepartment of Pharmacology and Toxicology, Augusta University, Augusta, Georgia.
Ailin TaoThe Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology, Guangzhou Medical University, Guangzhou, Guangdong, China.
Joe W RamosCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Stefan MoisyadiInstitute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.
Randall F HolcombeCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Wei JiaEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Lutz BirnbaumerNeurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; Institute for Biomedical Research (BIOMED), Universidad Católica Argentina, Buenos Aires, Argentina.
Xiqiao ZhouDepartment of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: zhouxiqiao@njmu.edu.cn.
Wen-Ming ChuCancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology, Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address: wchu@cc.hawaii.edu.
University of Hawaiʻi at Mānoa · USJiangsu Province Hospital · CNUniversity of Colorado Anschutz Medical Campus · USAugusta University · USBrown University · USNanjing Drum Tower Hospital · CNPontificia Universidad Católica Argentina · ARSecond Affiliated Hospital of Guangzhou Medical University · CNUniversity of California, Los Angeles · USUniversity of Chicago · USWuhan University · CN
Funding
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2MTransgenic Mouse, ICSI and IVF CoreP20GM103457 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI WARD, WILLIAM S · 2012 to 2018
$12.9MSmall Grants ProgramP30GM114737 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI NERURKAR, VIVEK RAMCHANDRA · 2015 to 2022
$8.1MTransmembrane Signaling MechanismsZ01ES101643 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BIRNBAUMER, LUTZ · 2003 to 2008
$5.1MGut microbiota mediated bile acid alterations in hepatic carcinogenesisU01CA188387 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI JIA, WEI · 2015 to 2019
$2.7MMechansim of activation of innate immunity by ISS-DNAR01AI054128 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI CHU, WEN-MING · 2002 to 2013
$2.7MRole of PTPN11 in Cartilage Stem Cells and TumorigenesisR01AR066746 · NIAMS · RHODE ISLAND HOSPITAL · PI YANG, WENTIAN · 2015 to 2019
$1.8MMolecular Insights into the Fanconi Anemia Tumor Suppressor Signaling PathwayR01CA188251 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI FEI, PEIWEN · 2014 to 2018
$1.6MAnterograde transport and signal regulation of GPCRsR01GM118915 · NIGMS · AUGUSTA UNIVERSITY · PI WU, GUANGYU · 2016 to 2019
$1.3MIntramural NIH HHS Z01 ES101643NCI NIH HHS P30 CA071789NCI NIH HHS R01 CA188251NCI NIH HHS U01 CA188387NIAID NIH HHS R01 AI054128NIGMS NIH HHS P20 GM103457NIGMS NIH HHS P30 GM114737NIGMS NIH HHS R01 GM118915
Abstract
BACKGROUND &
aimsInterleukin 6 (IL6) and tumor necrosis factor contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the development of CAC in mice and humans.
methodsB6;129 wild-type (control) or mice with disruption of Gnai1, Gnai2, and/or Gnai3 or conditional disruption of Gnai2 in CD11c
resultsGNAI1 and GNAI3 (GNAI1;3) double-knockout (DKO) mice developed more severe colitis after administration of DSS and significantly more colonic tumors than control mice after administration of AOM plus DSS. Development of increased tumors in DKO mice was not associated with changes in fecal microbiomes but was associated with activation of nuclear factor (NF) κB and signal transducer and activator of transcription (STAT) 3; increased levels of GNAI2, nitric oxide synthase 2, and IL6; increased numbers of CD4
conclusionsGNAI1;3 suppresses DSS-plus-AOM-induced colon tumor development in mice, whereas expression of GNAI2 in CD11c
Indexed as
AnimalsBiopsy, NeedleCarcinogenesisCell Transformation, NeoplasticColitisColonic NeoplasmsDisease Models, AnimalDown-RegulationFemaleGene Expression Regulation, NeoplasticGTP-Binding Protein alpha Subunits, Gi-GoImmunohistochemistryInterleukin-16MaleMiceMice, Inbred C57BLGnai1 protein, mouseGnai3 protein, mouseGTP-Binding Protein alpha Subunits, Gi-GoInterleukin-16CACIBDMouse ModelTranscription Factor
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