ArticleInvestigative ophthalmology & visual science2019
Mechanical Deformation of Human Optic Nerve Head and Peripapillary Tissue in Response to Acute IOP Elevation.
Article in Investigative ophthalmology & visual science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- Exploring Structural and Vascular Changes of the Optic Nerve Head After Trabeculectomy in Primary Open-Angle Glaucoma.Vision (Basel, Switzerland) · 2025Article
- Peripapillary scleral stiffening increases optic nerve head shear deformation in porcine eyes during IOP elevation.Experimental eye research · 2025Article
- Comparing continuum and direct fiber models of soft tissues. An ocular biomechanics example reveals that continuum models may artificially disrupt the strains at both the tissue and fiber levels.bioRxiv : the preprint server for biology · 2024Article
- Biomechanical Correlations Between the Cornea and the Optic Nerve Head.Investigative ophthalmology & visual science · 2024Article
- Quantitative Optical Coherence Elastography of the Optic Nerve Head In Vivo.IEEE transactions on bio-medical engineering · 2024Article
- Comparison of the Biomechanics of the Mouse Astrocytic Lamina Cribrosa Between Glaucoma and Optic Nerve Crush Models.Investigative ophthalmology & visual science · 2023Article
- Quantitative evaluation of biomechanical properties of optic nerve head by using acoustic radiation force optical coherence elastography.Neurophotonics · 2023Article
- Three-Dimensional Ultrasound Elastography Detects Age-Related Increase in Anterior Peripapillary Sclera and Optic Nerve Head Compression During IOP Elevation.Investigative ophthalmology & visual science · 2023Article
- Neuroretinal Rim Response to Transient Intraocular Pressure Challenge Predicts the Extent of Retinal Ganglion Cell Loss in Experimental Glaucoma.Investigative ophthalmology & visual science · 2023Article
- Article
- Regional differences of the sclera in the ocular hypertensive rat model induced by circumlimbal suture.Eye and vision (London, England) · 2023Article
- Retinal astrocyte morphology predicts integration of vascular and neuronal architecture.Frontiers in neuroscience · 2023Article
- A Workflow for Three-Dimensional Reconstruction and Quantification of the Monkey Optic Nerve Head Vascular Network.Journal of biomechanical engineering · 2022Article
- Mechanical Deformation of Peripapillary Retina in Response to Acute Intraocular Pressure Elevation.Journal of biomechanical engineering · 2022Article
- Microstructural Deformations Within the Depth of the Lamina Cribrosa in Response to Acute In Vivo Intraocular Pressure Modulation.Investigative ophthalmology & visual science · 2022Article
- Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy.Experimental eye research · 2022Article
- Finite element modeling of the complex anisotropic mechanical behavior of the human sclera and pia mater.Computer methods and programs in biomedicine · 2022Article
- Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo.Experimental eye research · 2021Article
- Modeling the biomechanics of the lamina cribrosa microstructure in the human eye.Acta biomaterialia · 2021Article
- Ultrasonic elastography to assess biomechanical properties of the optic nerve head and peripapillary sclera of the eye.Ultrasonics · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Purpose: To measure the deformation of the human optic nerve head (ONH) and peripapillary tissue (PPT) in response to acute intraocular pressure (IOP) elevation. Methods: The ONH and PPT of 14 human donor globes were imaged with high-frequency ultrasonography during inflation testing from 5 to 30 mm Hg. A correlation-based speckle tracking algorithm was used to compute tissue displacements, and the through-thickness, in-plane, and shear strains were calculated by using least-squares strain estimation methods. The ONH and PPT were segmented along the anterior-posterior direction and the nasal-temporal direction. Regional displacements and strains were analyzed and compared. Results: The ONH displaced more posteriorly than the PPT in response to an acute IOP increase. Scleral canal expansion was minimal but correlated with ONH posterior displacement at all IOP levels. Through-thickness compression was concentrated in the anterior of both the ONH and the PPT. Shear was concentrated in the vicinity of the canal with higher shear in the peripheral ONH than the central ONH and higher shear in the PPT near the scleral canal than that further away from the canal. Conclusions: High-resolution ultrasound speckle tracking showed a displacement mismatch between the ONH and the PPT, larger compressive strains in the direction of IOP loading in the anterior ONH and PPT, and higher shear strains in the periphery of ONH in response to acute IOP elevation in the human eye. These findings delineate the deformation patterns within and around the ONH and may help understand IOP-associated optic nerve damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.