Evidence map›Paper›PMID 30835188›Full record

ArticleRadiology2019

Association between Nonalcoholic Fatty Liver Disease at CT and Coronary Microvascular Dysfunction at Myocardial Perfusion PET/CT.

Tomas Vita, David J Murphy, Michael T Osborne, Navkaranbir S Bajaj, Abhishek Keraliya, Sophia Jacob, Angel Joel Diaz Martinez, Ariana Nodoushani, Paco Bravo, Jon Hainer and 7 more

Open access · greenAbstract read
In one paragraph

Article in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 1 institution in 3 countries.

Tomas VitaFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).
David J MurphyFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).ORCID 0000-0002-0361-672X
Michael T OsborneFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).ORCID 0000-0003-1001-1718
Navkaranbir S BajajFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).ORCID 0000-0002-4605-0797
Abhishek KeraliyaFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).ORCID 0000-0001-7850-8144
Sophia JacobFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).ORCID 0000-0001-6733-0184
Angel Joel Diaz MartinezFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).
Ariana NodoushaniFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).
Paco BravoFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).ORCID 0000-0002-0022-4376
Jon HainerFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).ORCID 0000-0002-0572-912X
Courtney F BibboFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).ORCID 0000-0003-2937-0622
Michael L SteignerFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).ORCID 0000-0002-3742-4267
Viviany R TaquetiFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).ORCID 0000-0002-0136-3781
Hicham SkaliFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).ORCID 0000-0002-5629-4138
Ron BlanksteinFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).
Marcelo F Di CarliFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).
Sharmila DorbalaFrom the Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology (T.V., D.J.M., M.T.O., N.S.B., A.K., A.J.D.M., P.B., J.H., C.F.B., M.L.S., V.R.T., H.S., R.B., M.F.D.C., S.D.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (S.J., A.N., J.H., C.F.B., V.R.T., M.F.D.C., S.D.), and Cardiovascular Division (V.R.T., H.S., R.B., M.F.D.C., S.D.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Cardiac MR/PET/CT Program, Departments of Medicine and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.T.O.); and Division of Cardiology, Department of Internal Medicine and Radiology, University of Alabama at Birmingham, Birmingham, Ala (N.S.B.).ORCID 0000-0003-1462-1185
Brigham and Women's Hospital · US

Funding

Institutional Career Development CoreKL2TR002542 · NCATS · HARVARD MEDICAL SCHOOL · PI BREDELLA, MIRIAM ANTOINETTE, RUTKOVE, SEWARD B. · 2018 to 2022
$8.7M
Noninvasive Cardiovascular Imaging Research Training ProgramT32HL094301 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Marcelo F DI CARLI · 2010 to 2026
$7.8M
Cardiac MR and CT ResearchT32HL076136 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, TOMAS G · 2004 to 2019
$4.9M
Extension to Coronary Flow Reserve to Assess Hidden Risk: Focus on Women, Heart Failure, and InflammationK23HL135438 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TAQUETI, VIVIANY R · 2017 to 2021
$1.1M
NCATS NIH HHS KL2 TR002542NHLBI NIH HHS K23 HL135438NHLBI NIH HHS T32 HL076136NHLBI NIH HHS T32 HL094301
6 · The paper itself

Abstract

Background Cardiovascular disease is a major cause of mortality in patients with nonalcoholic fatty liver disease (NAFLD). However, the association of NAFLD with coronary microvascular dysfunction is, to our knowledge, unknown. Purpose To determine whether coronary microvascular dysfunction is more prevalent in patients with NAFLD and to determine whether coronary microvascular dysfunction predicts major adverse cardiac events (MACE) independently of NAFLD. Materials and Methods This retrospective study (2006-2014) included patients without evidence of obstructive epicardial coronary artery disease and healthy left ventricular ejection fraction (≥40%) at a clinical rest and stress myocardial perfusion PET/CT. NAFLD was defined by a mean hepatic attenuation of less than 40 HU at CT and coronary microvascular dysfunction as a coronary flow reserve (CFR) of less than 2.0. A composite of all-cause mortality, myocardial infarction, coronary revascularization, and hospitalization because of heart failure comprised MACE (130 of 886 patients; 14.7%). The relation between NAFLD and MACE was assessed by using multivariable Cox regression analysis. Results Among 886 patients (mean age, 62 years ± 12 [standard deviation]; 631 women [mean age, 62 years ± 12 years] and 255 men [mean age, 61 years ± 12]; and ejection fraction, 63% ± 9), 125 patients (14.1%) had NAFLD and 411 patients (46.4%) had coronary microvascular dysfunction. Coronary microvascular dysfunction was more prevalent (64.8% vs 43.4%;

Indexed as

Coronary Artery DiseaseNon-alcoholic Fatty Liver DiseaseAgedFemaleHumansMaleMiddle AgedPositron Emission Tomography Computed TomographyRetrospective StudiesRisk Factors

Identifiers

PMID30835188
PMCPMC6492883
OpenAlexW2919620754

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