ReviewJournal of cardiovascular translational research2019
Adipokine Dysregulation and Insulin Resistance with Atherosclerotic Vascular Disease: Metabolic Syndrome or Independent Sequelae?
Review in Journal of cardiovascular translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 37 citations in OpenAlex.
- Trial
- Cardiometabolic Effects of Traditional South Asian Diets and the Growing Burden of Metabolic Syndrome.Archives of internal medicine research · 2026Article
- Retinol-binding Protein 4 as a Predictor of Cardiovascular Events after Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction.Journal of atherosclerosis and thrombosis · 2026Article
- Effects of nano-formulated tenoxicam on pancreatic alterations in dexamethasone-induced metabolic syndrome in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Multi-Targeted Intervention ofMetabolites · 2026Review
- Cardiorenal Protective Effects of Finerenone in Patients with Type 2 Diabetes Mellitus.Archives of internal medicine research · 2026Article
- Intricate interplay between ORMDL3, ER stress, and autophagy in the diabetic intestine.Molecular and cellular biochemistry · 2026Article
- Immune-mediated interactions between sarcopenia and atherosclerosis in aging.Immunity & ageing : I & A · 2025Review
- Associations of the fasting triglyceride glucose index with pulse wave velocity vary by age and gender.Archives of endocrinology and metabolism · 2025Article
- Adipokines in preeclampsia: disrupted signaling pathways and novel therapeutic strategies.European journal of medical research · 2025Review
- Aqueous Vernonia amygdalina leaf extract in drinking water mitigates aflatoxin B1 toxicity in broilers: effects on performance, biomarker analysis, and liver histology.Mycotoxin research · 2025Article
- Impact of Maternal Ultra-Processed Food Consumption and Preterm Birth on the Development of Metabolic Disorders in Offspring.Journal of pediatrics, perinatology and child health · 2025Article
- Effect of Metabolic Syndrome in the incidence of Rotator Cuff Injury and Recovery following Surgical Repair.Journal of surgery and research · 2025Article
- Nutrition, Gut Microbiota, and Epigenetics in the Modulation of Immune Response and Metabolic Health.Cardiology and cardiovascular medicine · 2025Article
- Biomarkers That Seem to Have the Greatest Impact on Promoting the Formation of Atherosclerotic Plaque in Current Scientific Research.Current issues in molecular biology · 2024Review
- Metabolic Syndrome and Psoriasis: Pivotal Roles of Chronic Inflammation and Gut Microbiota.International journal of molecular sciences · 2024Review
- Etiology, Pathophysiology, and Treatment Strategies in the Prevention and Management of Metabolic Syndrome.Archives of internal medicine research · 2024Article
- Adipose tissue specific CCL18 associates with cardiometabolic diseases in non-obese individuals implicating CD4Cardiovascular diabetology · 2023Article
- Age-associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis.Aging cell · 2023Article
- Discovery of Potential RAGE inhibitors using Receptor-Based Pharmacophore Modeling, High Throughput Virtual Screening and Docking Studies.Journal of biotechnology and biomedicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adipokine dysregulation and insulin resistance are two hallmark sequelae attributed to the current clinical definition of metabolic syndrome (MetS) that are also linked to atherosclerotic vascular disease. Here, we critically discuss the underlying pathophysiological mechanisms and the interplay between the two sequelae. Adipokine dysregulation is involved with decreased nitric oxide, vascular inflammation, and insulin resistance in itself to promote atherosclerosis. Insulin resistance is involved with endothelial dysfunction by direct and indirect mechanisms that also promote vascular inflammation and atherosclerosis. These mechanisms are discussed in atherosclerosis irrespective of MetS, and to evaluate the possibility of synergism in MetS. High retinol-binding protein-4 (RBP-4) and low cholesterol efflux in MetS may provide evidence of possible synergism and elevated atherosclerotic risk. An adverse adipokine panel that includes fetuin-A and adiponectin can potentially assess atherosclerotic risk in even those without MetS. Genetic possibilities may exist in atherosclerotic vascular diseases secondary to insulin resistance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.