Evidence map›Paper›PMID 30835008›Full record

ArticleMarine biotechnology (New York, N.Y.)2019

Gonadal microRNA Expression Profiles and Their Potential Role in Sex Differentiation and Gonadal Maturation of Mud Crab Scylla paramamosain.

Khor Waiho, Hanafiah Fazhan, Yin Zhang, Yueling Zhang, Shengkang Li, Huaiping Zheng, Wenhua Liu, Mhd Ikhwanuddin, Hongyu Ma

Abstract read
PubMed Publisher
In one paragraph

Article in Marine biotechnology (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. The miRNAsInternational journal of molecular sciences · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Khor WaihoGuangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China.
Hanafiah FazhanGuangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China.
Yin ZhangGuangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China.
Yueling ZhangGuangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China.
Shengkang LiGuangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China.
Huaiping ZhengGuangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China.
Wenhua LiuGuangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China.
Mhd IkhwanuddinSTU-UMT Joint Shellfish Research Laboratory, Shantou University, Shantou, 515063, China. ikhwanuddin@umt.edu.my.
Hongyu MaGuangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China. mahy@stu.edu.cn.ORCID http://orcid.org/0000-0003-2299-503X
Shantou University · CNUniversiti Malaysia Terengganu · MY

Funding

central organization china National Program for Support of Top-Notch Young ProfessionalsIntroduction of Outstanding Talents of Guangdong Province "Sail Plan" ProgramMinistry of Higher Education, Malaysia 53131National Key Research & Development Program of China 2018YFD0900201National Natural Science Foundation of China 31772837Program for Innovation and Enhancement of School of Department of Education of Guangdong Province 2017KCXTD014Shantou University NTF17006
6 · The paper itself

Abstract

Although the sexual dimorphism in terms of gonadal development and gametogenesis of mud crab has been described, the internal regulating mechanism and sex differentiation process remain unclear. A comparative gonadal miRNA transcriptomic study was conducted to identify miRNAs that are differentially expressed between testes and ovaries, and potentially uncover miRNAs that might be involved in sex differentiation and gonadal maturation mechanisms of mud crabs (Scylla paramamosain). A total of 10 known miRNAs and 130 novel miRNAs were identified, among which 54 were differentially expressed. Target gene prediction revealed a significant enrichment in 30 KEGG pathways, including some reproduction-related pathways, e.g. phosphatidylinositol signalling system and inositol phosphate metabolism pathways. Further analysis on six differentially expressed known miRNAs, six differentially expressed novel miRNAs and their reproduction-related putative target genes shows that both miRNAs and putative target genes showed stage-specific expression during gonadal maturation, suggesting their potential regulatory roles in sex differentiation and reproductive development. This study reveals the sex-biased miRNA profile and establishes a solid foundation for understanding the sex differentiation and gonadal maturation mechanisms of S. paramamosain.

Indexed as

AnimalsBrachyuraFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalGonadsMaleMicroRNAsSex DifferentiationSexual MaturationMicroRNAsGonadal maturationmicroRNAMud crabScylla paramamosainSex differentiation

Identifiers

PMID30835008
OpenAlexW2920342554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.