ArticleMetabolomics : Official journal of the Metabolomic Society2019
Thanatometabolomics: introducing NMR-based metabolomics to identify metabolic biomarkers of the time of death.
Article in Metabolomics : Official journal of the Metabolomic Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Soil microbial gene expression over one year of human decomposition.FEMS microbiology ecology · 2026Article
- Forensic Metabolomics: Enhancing PMI Estimation through Porcine Bone Tissue Profiling.Journal of proteome research · 2025Article
- AI-driven multi-omics modeling of myalgic encephalomyelitis/chronic fatigue syndrome.Nature medicine · 2025Article
- Article
- Metabolic Pattern of Brain Death-NMR-Based Metabolomics of Cerebrospinal Fluid.International journal of molecular sciences · 2025Article
- BioMapAI: Artificial Intelligence Multi-Omics Modeling of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome.bioRxiv : the preprint server for biology · 2025Article
- UPLC/Q-TOF MS-based femoral muscle metabolomic analysis under high-temperature: a proof of concept for postmortem interval estimation.Frontiers in medicine · 2025Article
- Multimodal Approaches Based on Microbial Data for Accurate Postmortem Interval Estimation.Microorganisms · 2024Review
- A fundamental study on postmortem submersion interval estimation by metabolomics analyzing of gastrocnemius muscle from submersed rat models in freshwater.International journal of legal medicine · 2024Article
- Postmortem metabolomics: influence of time since death on the level of endogenous compounds in human femoral blood. Necessary to be considered in metabolome study planning?Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Estimating the time of human decomposition based on skeletal muscle biopsy samples utilizing an untargeted LC-MS/MS-based proteomics approach.Analytical and bioanalytical chemistry · 2023Article
- Current Knowledge in Skin Metabolomics: Updates from Literature Review.International journal of molecular sciences · 2022Review
- Metabolomic Analysis Reveals That the Moor FrogAnimals : an open access journal from MDPI · 2022Article
- The Application of Metabolomics in Forensic Science with Focus on Forensic Toxicology and Time-of-Death Estimation.Metabolites · 2021Review
- NMR-based metabolomics of human cerebrospinal fluid identifies signature of brain death.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Applications of Metabolomics in Forensic Toxicology and Forensic Medicine.International journal of molecular sciences · 2021Review
- Riclinoctaose Attenuates Renal Ischemia-Reperfusion Injury by the Regulation of Macrophage Polarization.Frontiers in pharmacology · 2021Article
- Forensic NMR metabolomics: one more arrow in the quiver.Metabolomics : Official journal of the Metabolomic Society · 2020Review
- Comparative Decomposition of Humans and Pigs: Soil Biogeochemistry, Microbial Activity and Metabolomic Profiles.Frontiers in microbiology · 2020Article
- NMR metabolomics identifies over 60 biomarkers associated with Type II Diabetes impairment in db/db mice.Metabolomics : Official journal of the Metabolomic Society · 2019Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionDeath is the permanent cessation of the critical functions of the organism as a whole. However, the shutdown of a complex biological organism does not abruptly terminate at time of death. New high-throughput technologies allow the systematic investigation of the biochemical modulations occurring after death. Recent genomics studies have demonstrated that genes remain active after death, triggering upregulation of some genes and initiating feedback loops. These genes were mostly involved in pathways related to immunity, inflammation and cancer. These genetic modulations suggest many biochemical events persist after death, which can be captured using a metabolomics approach.
objectivesThis proof of concept work aimed to determine whether NMR spectroscopy could identify metabolomics changes occurring after death, and characterise the nature of these metabolomics modulations.
methodsHigh-resolution
resultsForty-three metabolites were associated with post mortem metabolomics modulations. Kidney, heart and spleen showed the highest metabolic perturbations. Conversely, skin and white adipose tissue were the least altered matrices. Early metabolic modulations were associated with energy metabolism and DNA synthesis, by contrast, late metabolomics modulations were associated with microbial metabolism.
conclusionsNMR has proven potential to determine the time of death based on post-mortem metabolomics modulations. This could be useful in the context of transplants, forensic studies and as internal quality control in metabolomics studies. Further investigations are required to validate these findings in humans in order to determine which compounds robustly reflect post-mortem metabolic fluctuations to accurately determine the time of death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.