ArticleEuropean child & adolescent psychiatry2019
Irritability in ADHD: association with later depression symptoms.
Article in European child & adolescent psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Diagnostic instruments for the assessment of disruptive mood dysregulation disorder: a systematic review of the literature.European child & adolescent psychiatry · 2023Pooled it
- Effects of Neurodevelopmental Disorders on the Clinical Presentations and Therapeutic Outcomes of Children and Adolescents with Severe Mood Disorders: A Multicenter Observational Study.Child psychiatry and human development · 2026Observational
- Irritability in preschool children with attention-deficit/hyperactivity disorder: Analysis of family environmental factors.JCPP advances · 2026Article
- Investigating the Symptom Presentation of Depression in Children With ADHD.Journal of attention disorders · 2026Article
- Associations between accelerometer-measured physical activity and sleep duration and health indicators in children and adolescents with attention-deficit hyperactivity disorder: A systematic review and meta-analysis.Journal of exercise science and fitness · 2026Review
- Investigating the reasons behind a later or missed diagnosis of attention-deficit/hyperactivity disorder in young people: A population cohort study.JCPP advances · 2025Article
- Irritability in young people with copy number variants associated with neurodevelopmental disorders (ND-CNVs).Translational psychiatry · 2024Article
- Intergenerational transmission of genetic risk for hyperactivity and inattention. Direct genetic transmission or genetic nurture?JCPP advances · 2024Article
- Altered Lateral Prefrontal Cortex Functioning During Emotional Interference Resistance Is Associated With Affect Lability in Adults With Persisting Symptoms of Attention-Deficit/Hyperactivity Disorder From Childhood.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- ADHD-related sex differences in emotional symptoms across development.European child & adolescent psychiatry · 2024Article
- Irritability, Negative Life Events and the Course of Anxiety and Depressive Symptoms in a Clinical Sample of Youth: A Longitudinal Study.JAACAP open · 2024Article
- A New Behavioral Paradigm for Frustrative Nonreward in Juvenile Mice.Biological psychiatry global open science · 2024Article
- Effects of non-invasive brain stimulation on emotion regulation in patients with attention deficit hyperactivity disorder: a systematic review.Frontiers in psychiatry · 2024Review
- Attention Deficit Hyperactivity Disorder Among Youth at Clinical High Risk of Psychosis.Schizophrenia bulletin open · 2024Article
- Robust caregiver-youth discrepancies in irritability ratings on the affective reactivity index: An investigation of its origins.Journal of affective disorders · 2023Article
- Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Psychometric Validation of the Greek Version of the Scale "Temper Loss" of the Questionnaire "Multidimensional Assessment Profile of Disruptive Behavior (MAP-DB)".Children (Basel, Switzerland) · 2022Article
- Article
- Depressive symptoms in youth with ADHD: the role of impairments in cognitive emotion regulation.European archives of psychiatry and clinical neuroscience · 2022Article
- Heterogeneous courses of obsessive-compulsive disorders-better data on a lifetime perspective urgently needed.European child & adolescent psychiatry · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Attention-deficit/hyperactivity disorder (ADHD) and depression commonly co-occur. Identifying children with ADHD at risk for later depression may allow early intervention and prevention. Irritability is one possible mechanism linking these two disorders. It is common in ADHD and associated with later depression in the general population. Cross-sectional studies suggest an association between irritability and depression in ADHD, but longitudinal research is limited. This study followed up a clinical ADHD sample longitudinally to examine: (1) the association between childhood irritability and later depression symptoms, and (2) whether irritability persistence is important in this association. At baseline, parents (n = 696) completed semi-structured interviews about their child (mean age = 10.9), providing information on child psychopathology, including irritability. A subsample (n = 249) was followed up after a mean of 5.4 years. Parent-completed Mood and Feelings Questionnaires provided information on depressive symptoms at follow-up. Parent-rated structured diagnostic interviews provided information on ADHD diagnosis and irritability at follow-up. Regression analyses examined associations between (i) baseline irritability and depression symptoms at follow-up, and (ii) persistent (vs. remitted) irritability and depression symptoms at follow-up. Analyses controlled for age, gender, depression symptoms, anxiety, ADHD symptoms, and ADHD medication at baseline. Baseline irritability was associated with depression symptoms at follow-up, but the association attenuated after controlling for anxiety and ADHD symptoms. Persistent irritability was associated with depression symptoms at follow-up, after including all covariates. Children with ADHD with persistent irritability are at elevated risk of developing depression symptoms. They may be a target for early intervention and prevention of depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.