ArticleJournal of clinical hypertension (Greenwich, Conn.)2019
C-reactive protein and incident hypertension in a worksite population of Japanese men.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Second Derivative of the Finger Photoplethysmogram Predicts the Risk of Developing Hypertension in Middle-Aged Men.Journal of atherosclerosis and thrombosis · 2025Article
- Impact of hypertension diagnosis on morbidity and mortality: a retrospective cohort study in primary care.BMC primary care · 2023Article
- The relationship between serum C-reactive protein and senile hypertension.BMC cardiovascular disorders · 2022Article
- Association of blood pressure and hypertension with radiographic damage among the patients with ankyloing spondylitis.Medicine · 2022Article
- Serum Calprotectin Level as an Inflammatory Marker in Newly Diagnosed Hypertensive Patients.International journal of hypertension · 2022Article
- C-reactive protein and incident hypertension in a worksite population of Japanese men.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation plays a key role in the pathogenesis of cardiovascular diseases via the development of atherosclerosis. Here, we evaluated the impact of serum C-reactive protein (CRP) and the white blood cell (WBC) count on the risk of hypertension in middle-aged Japanese men at a work site. We evaluated a total of 2991 Japanese male workers without hypertension who ranged in age from 18 to 64 years (mean age 40.4 ± 0.2 years) at a worksite in 2010. The hazard ratio (HR) for incident hypertension was estimated according to quartile levels of serum high-sensitivity CRP (hs-CRP) or WBC count. These men were followed up for 5 years from 2010 to 2015. During the follow-up period, 579 (19.4%) subjects developed hypertension. In a multivariable analysis, the risk of incident hypertension was significantly increased with higher hs-CRP levels: HR 1.00 (reference) for the lowest quartile, 1.39 (1.04-1.85) for the 2nd quartile, 1.46 (1.08-1.98) for the 3rd quartile, and 1.57 (1.17-2.11) for the highest quartile. In contrast, the WBC count was not associated with a greater risk of incident hypertension after multivariable adjustment. These findings suggest that higher levels of serum hs-CRP, but not the WBC count, are associated with the future incidence of hypertension in middle-aged Japanese men.
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