ArticleAging cell2019
Nontuberculous mycobacterium M. avium infection predisposes aged mice to cardiac abnormalities and inflammation.
Article in Aging cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Mycobacterium intracellulare M.i.198-A Promising Strain for Studying Pathogenesis of Nontuberculous Mycobacterial Pulmonary Disease (NTM-PD).Microbiology and immunology · 2026Review
- Cellular Senescence, Inflammaging and Cardiovascular Disease.Immunological reviews · 2026Review
- Successful endodontic treatment improves glucose and lipid metabolism: a longitudinal metabolomic study.Journal of translational medicine · 2025Article
- Gut commensal bacterium Bacteroides vulgatus exacerbates helminth-induced cardiac fibrosis through succinate accumulation.PLoS pathogens · 2025Article
- Multimodal machine learning-based model for differentiating nontuberculous mycobacteria fromFrontiers in public health · 2025Article
- Akkermansia muciniphila participates in the host protection against helminth-induced cardiac fibrosis via TLR2.PLoS pathogens · 2023Article
- Pseudomonas aeruginosa pulmonary infection results in S100A8/A9-dependent cardiac dysfunction.PLoS pathogens · 2023Article
- Sex, ancestry, senescence, and aging (SAnSA) are stark drivers of nontuberculous mycobacterial pulmonary disease.Journal of clinical tuberculosis and other mycobacterial diseases · 2022Review
- Aging influences the cardiac macrophage phenotype and function during steady state and during inflammation.Aging cell · 2021Article
- Cardiac Microlesions Form During Severe Bacteremic Enterococcus faecalis Infection.The Journal of infectious diseases · 2021Article
- Review
- The pathogenesis of cardiac microlesion formation during severe bacteremic infection.PLoS pathogens · 2020Review
- Latent tuberculosis infection associates with cardiac involvement in patients with sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2020Article
- Aging heart and infection.Aging · 2019Article
- Nontuberculous mycobacterium M. avium infection predisposes aged mice to cardiac abnormalities and inflammation.Aging cell · 2019Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Biological aging dynamically alters normal immune and cardiac function, favoring the production of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) and increased instances of cardiac distress. Cardiac failure is the primary reason for hospitalization of the elderly (65+ years). The elderly are also increasingly susceptible to developing chronic bacterial infections due to aging associated immune abnormalities. Since bacterial infections compound the rates of cardiac failure in the elderly, and this phenomenon is not entirely understood, the interplay between the immune system and cardiovascular function in the elderly is of great interest. Using Mycobacterium avium, an opportunistic pathogen, we investigated the effect of mycobacteria on cardiac function in aged mice. Young (2-3 months) and old (18-20 months) C57BL/6 mice were intranasally infected with M. avium strain 104, and we compared the bacterial burden, immune status, cardiac electrical activity, pathology, and function of infected mice against uninfected age-matched controls. Herein, we show that biological aging may predispose old mice infected with M. avium to mycobacterial dissemination into the heart tissue and this leads to cardiac dysfunction. M. avium infected old mice had significant dysrhythmia, cardiac hypertrophy, increased recruitment of CD45
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