Trial reportJournal of cardiovascular electrophysiology2019
How to implant a phrenic nerve stimulator for treatment of central sleep apnea?
Trial report in Journal of cardiovascular electrophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Automatic activation of neurostimulation for central sleep apnea results in high nightly usage.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Trial
- Win ratio analysis of transvenous phrenic nerve stimulation to treat central sleep apnoea in heart failure.ESC heart failure · 2025Trial
- How to implant a phrenic nerve stimulator for treatment of central sleep apnea?Journal of cardiovascular electrophysiology · 2019Trial
- Bridge over troubled water: A novel application of an occlusion balloon in phrenic nerve stimulator implantation.HeartRhythm case reports · 2026Article
- Recent advances in facilitating the translation of bioelectronic medicine therapies.Current opinion in biomedical engineering · 2025Article
- Phrenic Nerve Stimulation for Central Sleep Apnoea: When and Why?Cardiac failure review · 2025Review
- Safety and efficacy of phrenic nerve stimulation: A case series at the University of Oklahoma and review of the international literature.Surgical neurology international · 2025Article
- Phrenic nerve stimulation for treatment of central sleep apnea.Frontiers in sleep · 2023Review
- Transvenous Phrenic Nerve Stimulation for Treatment of Central Sleep Apnea: Five-Year Safety and Efficacy Outcomes.Nature and science of sleep · 2021Article
- Central Sleep Apnea in Patients with Heart Failure-How to Screen, How to Treat.Current heart failure reports · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 12 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCentral sleep apnea (CSA) is a breathing disorder caused by the intermittent absence of central respiratory drive. Transvenous phrenic nerve stimulation is a new therapeutic option, recently approved by the FDA , for the treatment of CSA.
objectiveTo describe the technique used to implant the transvenous phrenic nerve stimulation system (the remedē System, Respicardia, Inc).
methodsThe remedē System is placed in the pectoral region, typically on the right side. A single stimulation lead is placed in either the left pericardiophrenic vein (PPV) or the right brachiocephalic vein (RBC). A sensing lead is placed into the azygous vein to detect respiration.
resultsIn the remedē System Pivotal trial, 147 of 151 (97%) patients were successfully implanted with the system. Sixty-two percent of stimulation leads were placed in the PPV and 35% in the RBC. Mean procedure time was 2.7 ± 0.8 hours and 94% of patients were free from implant-related serious adverse events through 6 months.
conclusionIn patients with CSA, transvenous phrenic nerve stimulation is an effective and safe therapy with an implant procedure similar to that of cardiac implantable electronic devices.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.