Evidence map›Paper›PMID 30834441›Full record

Trial reportThe American journal of clinical nutrition2019

Coffee consumption and plasma biomarkers of metabolic and inflammatory pathways in US health professionals.

Dong Hang, Ane Sørlie Kværner, Wenjie Ma, Yang Hu, Fred K Tabung, Hongmei Nan, Zhibin Hu, Hongbing Shen, Lorelei A Mucci, Andrew T Chan and 2 more

2 registry-linked trialsAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 59 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03419455 no registry record found
NCT06330727 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effects of Three-Month Coffee Consumption on Metabolic Biomarkers in Adults With Prediabetes and Obesity: a Randomized, Double-blind, Placebo-controlled Clinical Trial

TypeinterventionalSponsorNanjing First Hospital, Nanjing Medical UniversityRan2024 to 2024Enrolled100ConditionsPrediabetesArmsCoffee capsule, Corn starch capsule
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Intermittent hypoxia and caffeine in infants born preterm: the ICAF Randomized Clinical Trial.Archives of disease in childhood. Fetal and neonatal edition · 2026
    Trial
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Dong HangDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Ane Sørlie KværnerDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Wenjie MaClinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Yang HuDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA.
Fred K TabungDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA.
Hongmei NanDepartment of Epidemiology, Richard M Fairbanks School of Public Health, Indiana University, and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN.
Zhibin HuDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Hongbing ShenDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Lorelei A MucciDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA.
Andrew T ChanDepartment of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, MA.
Edward L GiovannucciDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA.
Mingyang SongDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA.

Funding

Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Pro-inflammatory and Hyper-insulinemic Dietary Patterns and Colorectal Cancer Risk: Role of the MetabolomeR00CA207736 · NCI · OHIO STATE UNIVERSITY · PI TABUNG, FRED KINYUY · 2018 to 2020
$747k
Marine Omega-3 Polyunsaturated Fatty Acid, Gut Microbiome, and Colorectal Cancer PreventionR00CA215314 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI SONG, MINGYANG · 2018 to 2020
$679k
Proinflammatory and hyperinsulinemic dietary patterns and colorectal cancer risk: role of the metabolomeK99CA207736 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI TABUNG, FRED KINYUY · 2016 to 2017
$276k
Marine Omega-3 Polyunsaturated Fatty Acid, Gut Microbiome, and Colorectal Cancer PreventionK99CA215314 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SONG, MINGYANG · 2018 to 2018
$179k
NCI NIH HHS K99 CA207736NCI NIH HHS K99 CA215314NCI NIH HHS R00 CA207736NCI NIH HHS R00 CA215314NCI NIH HHS R01 CA049449NCI NIH HHS U01 CA167552NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107
6 · The paper itself

Abstract

backgroundCoffee consumption has been linked to lower risk of various health outcomes. However, the biological pathways mediating the associations remain poorly understood.

objectivesThe aim of this study was to assess the association between coffee consumption and concentrations of plasma biomarkers in key metabolic and inflammatory pathways underlying common chronic diseases.

methodsWe investigated the associations of total, caffeinated, and decaffeinated coffee consumption with 14 plasma biomarkers, including C-peptide, insulin-like growth factor 1 (IGF-1), IGF binding protein (IGFBP) 1, IGFBP-3, estrone, total and free estradiol, total and free testosterone, sex hormone-binding globulin (SHBG), total adiponectin, high-molecular-weight (HMW) adiponectin, leptin, C-reactive protein (CRP), interleukin 6 (IL-6), and soluble tumor necrosis factor receptor 2 (sTNFR-2). Data were derived from 2 cohorts of 15,551 women (Nurses' Health Study) and 7397 men (Health Professionals Follow-Up Study), who provided detailed dietary data before blood draw and were free of diabetes, cardiovascular disease, or cancer at the time of blood draw. Multivariable linear regression was used to calculate the percentage difference of biomarker concentrations comparing coffee drinkers with nondrinkers, after adjusting for a variety of demographic, clinical, and lifestyle factors.

resultsCompared with nondrinkers, participants who drank ≥4 cups of total coffee/d had lower concentrations of C-peptide (-8.7%), IGFBP-3 (-2.2%), estrone (-6.4%), total estradiol (-5.7%), free estradiol (-8.1%), leptin (-6.4%), CRP (-16.6%), IL-6 (-8.1%), and sTNFR-2 (-5.8%) and higher concentrations of SHBG (5.0%), total testosterone (7.3% in women and 5.3% in men), total adiponectin (9.3%), and HMW adiponectin (17.2%). The results were largely similar for caffeinated and decaffeinated coffee.

conclusionOur data indicate that coffee consumption is associated with favorable profiles of numerous biomarkers in key metabolic and inflammatory pathways. This trial was registered at clinicaltrials.gov as NCT03419455.

Indexed as

AdiponectinAdultAgedBiomarkersCoffeeCohort StudiesC-PeptideC-Reactive ProteinEstradiolFemaleFollow-Up StudiesHealth PersonnelHumansInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 3Interleukin-6AdiponectinBiomarkersCoffeeC-PeptideC-Reactive ProteinEstradiolIGFBP1 protein, humanIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 3Interleukin-6Sex Hormone-Binding GlobulinTestosteroneadipokinecoffee consumptioninflammationinsulinsex hormone

Identifiers

PMID30834441
PMCPMC6408210

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.