ArticlemSystems
Longitudinal Microbiome Composition and Stability Correlate with Increased Weight and Length of Very-Low-Birth-Weight Infants.
Article in mSystems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Determinants of the Very Low-Birth-Weight Infant's Intestinal Microbiome: A Systematic Review.The Journal of perinatal & neonatal nursingPooled it
- Pooled it
- Maternal diet shapes neonatal microbiome ontogenesis and neurometabolic resilience.Gut microbes · 2026Article
- Decoding the HMO‒microbiome axis: bridging maternal milk to infant health outcomes.Gut microbes · 2026Review
- Human milk microbiome as a modulator of the early-life gut-brain axis: mechanisms and translational opportunities for neurodevelopment.Journal of translational medicine · 2026Review
- Gut microbiota and metabolome signatures in preterm infants with high versus low risk for neurodevelopmental impairment: a prospective, matched, longitudinal multi-omics study.Frontiers in cellular and infection microbiology · 2026Article
- Perinatal morphine exposure induces long-term changes in the intestinal microbiota of male and female rats.Brain, behavior, and immunity · 2025Article
- Distribution of microsporidia in preterm and full-term infant gut microbiomes and implications for host health.Frontiers in pediatrics · 2025Article
- How human milk shapes the gut microbiota in preterm infants: potential for optimizing early-life microbial development.Microbiome research reports · 2025Article
- Horizontal transmission of symbiotic bacteria and host selective sweep in the giant clamISME communications · 2025Article
- Maternal characteristics are associated with human milk anti-inflammatory proteins in two populations.Scientific reports · 2024Article
- Antibiotic-induced collateral damage to the microbiota and associated infections.Nature reviews. Microbiology · 2023Review
- Gut microbiome diversity, variability, and latent community types compared with shifts in body weight during the freshman year of college in dormitory-housed adolescents.Gut microbes · 2023Observational
- Perinatal Morphine Exposure Induces Long-Term Changes in the Intestinal Microbiota of Male and Female Rats.bioRxiv : the preprint server for biology · 2023Article
- Longitudinal development of the airway metagenome of preterm very low birth weight infants during the first two years of life.ISME communications · 2023Article
- The impact of early empirical antibiotics treatment on clinical outcome of very preterm infants: a nationwide multicentre study in China.Italian journal of pediatrics · 2023Article
- Premature Infant Gut Microbiome relationships with childhood behavioral scales: preliminary insights.Frontiers in nutrition · 2023Article
- Gut Microbes and Circulating Cytokines in Preterm Infants with Growth Failure.The Journal of nutrition · 2023Article
- Relationships of the very low birth weight infant microbiome with neurodevelopment at 2 and 4 years of age.Developmental psychobiology · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The microbiomes of 83 preterm very-low-birth-weight (VLBW) infants and clinical covariates were analyzed weekly over the course of their initial neonatal intensive care unit (NICU) stay, with infant growth as the primary clinical outcome. Birth weight significantly correlated with increased rate of weight gain in the first 6 weeks of life, while no significant relationship was observed between rate of weight gain and feeding type. Microbial diversity increased with age and was significantly correlated with weight gain and percentage of the mother's own milk. As expected, infants who received antibiotics during their NICU stay had significantly lower alpha diversity than those who did not. Of those in the cohort, 25 were followed into childhood. Alpha diversity significantly increased between NICU discharge and age 2 years and between age 2 years and age 4 years, but the microbial alpha diversity of 4-year-old children was not significantly different from that of mothers. Infants who showed improved length over the course of their NICU stay had significantly more volatile microbial beta diversity results than and a significantly decreased microbial maturity index compared with infants who did not; interestingly, all infants who showed improved length during the NICU stay were delivered by Caesarean section. Microbial beta diversity results were significantly different between the time of the NICU stay and all other time points (for children who were 2 or 4 years old and mothers when their children were 2 or 4 years old).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.