Evidence map›Paper›PMID 30834305›Full record

ArticleeNeuro

Selective Activation of Cholecystokinin-Expressing GABA (CCK-GABA) Neurons Enhances Memory and Cognition.

Paul D Whissell, Jee Yoon Bang, Ikram Khan, Yu-Feng Xie, Gustavo M Parfitt, Martine Grenon, Nicholas W Plummer, Patricia Jensen, Robert P Bonin, Jun Chul Kim

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Paul D WhissellPsychology.
Jee Yoon BangCell and Systems Biology, University of Toronto, Toronto, Ontario, Canada M5S 3G3.
Ikram KhanCell and Systems Biology, University of Toronto, Toronto, Ontario, Canada M5S 3G3.
Yu-Feng XieLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, M5S 3M2, Canada.ORCID 0000-0001-8384-4177
Gustavo M ParfittPsychology.
Martine GrenonCell and Systems Biology, University of Toronto, Toronto, Ontario, Canada M5S 3G3.
Nicholas W PlummerNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709.
Patricia JensenNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709.
Robert P BoninLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, M5S 3M2, Canada.
Jun Chul KimPsychology.ORCID 0000-0001-9920-3307
University of Toronto · CANational Institutes of Health · US

Funding

Central Noradrenergic Neuron Subtype Development and FunctionZIAES102805 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JENSEN, PATRICIA · 2010 to 2025
$33.9M
CIHR MOP 496401NIEHS NIH HHS ZIA ES102805
6 · The paper itself

Abstract

Cholecystokinin-expressing GABAergic (CCK-GABA) neurons are perisomatic inhibitory cells that have been argued to regulate emotion and sculpt the network oscillations associated with cognition. However, no study has selectively manipulated CCK-GABA neuron activity during behavior in freely-moving animals. To explore the behavioral effects of activating CCK-GABA neurons on emotion and cognition, we utilized a novel intersectional genetic mouse model coupled with a chemogenetic approach. Specifically, we generated triple transgenic

Indexed as

AnimalsCholecystokininCognitionEmotionsGABAergic NeuronsHippocampusMaleMemoryMice, Inbred C57BLMice, TransgenicSocial BehaviorTissue Culture TechniquesCholecystokininanxietycholecystokinincognitionGABAmemoryperisomatic

Identifiers

PMID30834305
PMCPMC6397954
OpenAlexW2920329388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.