Evidence map›Paper›PMID 30834280›Full record

ArticleOrthopaedic journal of sports medicine2019

Efficacy and Tolerability of Progen, a Nutritional Supplement Based on Innovative Plasma Proteins, in ACL Reconstruction: A Multicenter Randomized Controlled Trial.

Emilio López-Vidriero, Ramón Olivé-Vilas, David López-Capapé, Luisa Varela-Sende, Rosa López-Vidriero, Luís Til-Pérez

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic journal of sports medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03355651 nacompletednot on this map

Prospective Study for Assess Efficacy and Tolerability of an Oral Supplement Based on Collagen, HC-15 and Plasmatic Proteins, in the Recovery of ACL After Surgery: a Multicenter, Randomized, Controlled Trial

TypeinterventionalSponsorOPKO Health, Inc.Ran2015 to 2017Enrolled80ConditionsACL ReconstructionArmsPROGEN
NCT06379997 narecruitingnot on this mapstarted 2024, after this paper: background citation

Efficacy of Oral Hyaluronic Acid and Collagen Supplementation Compared With Hyaluronic Acid Infiltration Treatment in Rotator Cuff Tendinopathies: A Prospective Study

TypeinterventionalSponsorI.R.C.C.S. Fondazione Santa LuciaRan2024 to 2025Enrolled50ConditionsTendinitis of Shoulder, Hyaluronic Acid, Dietary Supplements, Shoulder PainArmsCollagen, Hyaluronic Acid, Vitamin C, and Manganese, Intra-articular infiltration
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Heterologous production of chondroitin.Biotechnology reports (Amsterdam, Netherlands) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Emilio López-VidrieroISMEC, Sevilla, Spain.
Ramón Olivé-VilasCST Consorci Sanitari de Terrassa, Barcelona, Spain.
David López-CapapéClinica CEMTRO, Madrid, Spain.
Luisa Varela-SendeOPKO Health, Barcelona, Spain.
Rosa López-VidrieroISMEC, Sevilla, Spain.
Luís Til-PérezCST Consorci Sanitari de Terrassa, Barcelona, Spain.
Clínica Rementería · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNew biologic strategies are arising to enhance healing and improve the clinical outcome of anterior cruciate ligament (ACL) reconstruction. PURPOSE: To evaluate the efficacy of a new oral nutritional supplement (Progen) that contains hydrolyzed collagen peptides and plasma proteins, a hyaluronic acid-chondroitin sulfate complex, and vitamin C. STUDY

designRandomized controlled trial; Level of evidence, 2.

methodsThe study included patients who underwent ACL reconstruction with hamstring autografts using the same fixation method. All patients received the same analgesia and physical therapy (PT) protocol and were randomized to receive either the nutritional supplement (supplemented group) or no additional therapy (control group). Patients were followed up at days 7, 30, 60, and 90. Pain was assessed by use of a visual analog scale (VAS) and by analgesic consumption. Clinical outcome was assessed via International Knee Documentation Committee (IKDC) score and the number of PT sessions. Perceived efficacy and tolerability were rated on a 5-point Likert scale. Graft maturation was assessed by a blinded musculoskeletal radiologist using magnetic resonance imaging. The number of adverse events (AEs) was recorded.

resultsThe intention-to-treat analysis included 72 patients, 36 allocated to the supplemented group and 36 to the control group, with no significant differences regarding demographic and preoperative characteristics. Both groups showed significant improvement in pain and function (measured by VAS and IKDC scores) during the 90-day follow-up period (

conclusionThe combination of the nutritional supplement and PT after ACL reconstruction improved pain, clinical outcome, and graft maturation. Nutritional supplementation showed higher efficacy during the second month of recovery, without causing AEs. REGISTRATION: NCT03355651 (ClinicalTrials.gov identifier).

Indexed as

anterior cruciate ligament tearschondroitin sulfatecollagendietary supplementationshyaluronic acidplatelet-rich plasmavitamin C

Identifiers

PMID30834280
PMCPMC6393838
OpenAlexW2915398980

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.