Evidence map›Paper›PMID 30834186›Full record

ArticlePeerJ2019

TRPV1 protects renal ischemia-reperfusion injury in diet-induced obese mice by enhancing CGRP release and increasing renal blood flow.

Beihua Zhong, Shuangtao Ma, Donna H Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Beihua ZhongDivision of Nanomedicine and Molecular Intervention, Department of Medicine, Michigan State University, East Lansing, MI, USA.
Shuangtao MaDivision of Nanomedicine and Molecular Intervention, Department of Medicine, Michigan State University, East Lansing, MI, USA.
Donna H WangDivision of Nanomedicine and Molecular Intervention, Department of Medicine, Michigan State University, East Lansing, MI, USA.
Michigan State University · US

Funding

Vanilloid Sensitive Sensory Nerves and Salt SensitivityR01HL073287 · NHLBI · MICHIGAN STATE UNIVERSITY · PI WANG, DONNA H · 2004 to 2011
$2.7M
Molecular Sensing of Sodium Homeostasis: Anandamide RoleR01DK067620 · NIDDK · MICHIGAN STATE UNIVERSITY · PI WANG, DONNA H · 2005 to 2009
$1.4M
RENAL ANGIOTENSIN II RECEPTOR AND SODIUM INTAKER01HL057853 · NHLBI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI WANG, DONNA H · 1998 to 2007
$1.1M
NHLBI NIH HHS R01 HL057853NHLBI NIH HHS R01 HL073287NIDDK NIH HHS R01 DK067620
6 · The paper itself

Abstract

backgroundObesity is a major risk factor for end-stage renal disease. Using transient receptor potential vanilloid 1 knockout (TRPV1

methodsTRPV1

resultsThe Western diet significantly increased body weight and fasting blood glucose levels in both TRPV1

conclusionThese results indicate that TRPV1 plays a protective role in WD-induced exacerbation of renal I/R injury probably through enhancing CGRP release and increasing renal blood flow.

Indexed as

Calcitonin gene-related peptideRenal blood flowRenal ischemia-reperfusionTRPV1Western diet

Identifiers

PMID30834186
PMCPMC6397633
OpenAlexW2917337435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.