ArticleFrontiers in microbiology2019
The Association Between Documentation of Koplik Spots and Laboratory Diagnosis of Measles and Other Rash Diseases in a National Measles Surveillance Program in Japan.
Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 14 citations in OpenAlex.
- Whole-genome sequencing reveals a previously unrecognized measles virus cluster in Burundi.PloS one · 2026Article
- Factors associated with laboratory-confirmed measles cases during the 2023 and 2024 outbreaks in Tanzania-a mixed-methods study.Frontiers in public health · 2026Article
- The Epidemiology and Diagnosis of Measles—Special Aspects Relating to Low Incidence.Deutsches Arzteblatt international · 2024Review
- Clinical characteristics of adult inpatients with Measles in Beijing from 2010 to 2021: a retrospective analysis.BMC infectious diseases · 2023Article
- A Case Report of Secondary Syphilis Co-Infected with Measles: A Diagnostic Dilemma with Fever and Rash.Tropical medicine and infectious disease · 2022Article
- A Major Regional Measles Outbreak: Description of Hospitalized Cases in 2017-2018 at Bordeaux University Hospital, France.Open forum infectious diseases · 2020Article
- An evaluation of the clinical features of measles virus infection for diagnosis in children within a limited resources setting.BMC pediatrics · 2020Article
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Koplik spots are considered a disease-specific sign for measles, although comprehensive virological studies have not been conducted to date. In Japan, a national survey of 3023 measles and measles-suspected cases was conducted between 2009 and 2014 using polymerase chain reaction (PCR) or reverse transcription PCR (RT-PCR) to detect various rash/fever-associated viruses. Koplik spots were observed in 717 of 3023 cases (23.7%). Among these, the measles virus was detected in 202 cases (28.2%), while the rubella virus was detected in 125 cases (17.4%). Other viruses were detected in 51 cases having the spots (7.1%). In some of the cases with spots, two or three viruses, such as the rubella virus, parvovirus, and human herpesvirus type 6 were also detected. The sensitivity and specificity of Koplik spots as a diagnostic marker for measles were 48 and 80%, respectively. The results suggested that Koplik spots might appear not only in measles but also in other viral infections, such as rubella, as a clinical sign.
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