ArticleFrontiers in neuroanatomy2019
Papez Circuit Observed by
Article in Frontiers in neuroanatomy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Deep brain stimulation of the hypothalamic region: a systematic review.Acta neurochirurgica · 2025Pooled it
- Effectiveness of deep brain stimulation on refractory aggression in pediatric patients with autism and severe intellectual disability: meta-analytic review.BMC pediatrics · 2024Pooled it
- High definition transcranial direct current stimulation as an intervention for cognitive deficits in Alzheimer's dementia: A randomized controlled trial.The journal of prevention of Alzheimer's disease · 2025Trial
- Limbic System Glioblastoma Extending to the Papez Circuit: A Case Report.Journal of clinical practice and research · 2026Article
- Comparison of reduced FOV diffusion-weighted imaging of rectal cancer at 5.0T ultra-high field versus 3.0T MRI: image quality and histopathological T staging.BMC medical imaging · 2025Article
- Hippocampal architecture viewed through the eyes of methodological development.Anatomical science international · 2025Review
- Associations of tau, Aβ, and brain volume of the Papez circuit with cognition in Alzheimer's disease.European archives of psychiatry and clinical neuroscience · 2025Article
- 7T magnetic resonance imaging-based investigation of the correlation between mammillary body structure and cognitive impairment in patients with spinocerebellar ataxia type 3.Psychoradiology · 2025Article
- Clinical Feasibility of 5.0 T MRI/MRCP in Characterizing Pancreatic Cystic Lesions: Comparison with 3.0 T and MDCT.Diagnostics (Basel, Switzerland) · 2024Article
- High angular resolution diffusion-weighted imaging and higher order tractography of the white matter tracts in the anterior thalamic area: Insights into deep brain stimulation targeting.Neuroimage. Reports · 2024Article
- Is the Papez circuit the location of the elusive episodic memory engram?IBRO neuroscience reports · 2024Article
- The subcortical default mode network and Alzheimer's disease: a systematic review and meta-analysis.Brain communications · 2024Article
- Mapping mesoscale connectivity within the human hippocampus.NeuroImage · 2023Article
- Time to retire the serial Papez circuit: Implications for space, memory, and attention.Neuroscience and biobehavioral reviews · 2022Review
- The anterior thalamic nuclei: core components of a tripartite episodic memory system.Nature reviews. Neuroscience · 2022Review
- Alteration of Neural Pathways and Its Implications in Alzheimer's Disease.Biomedicines · 2022Review
- Compromised mammillary body connectivity and psychotic symptoms in mice with di- and mesencephalic ablation of ST8SIA2.Translational psychiatry · 2022Article
- Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson's Disease.Frontiers in aging neuroscience · 2022Article
- Cingulum bundle connectivity considering the double-layered cingulate cortex using diffusion-weighted MRI.Neuroimage. Reports · 2021Article
- Track-Density Ratio Mapping With Fiber Types in the Cerebral Cortex Using Diffusion-Weighted MRI.Frontiers in neuroanatomy · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Papez circuit has been considered as an important anatomical substrate involved in emotional experience. However, the circuit remains difficult to elucidate in the human brain due to the resolution limit of current neuroimaging modalities. In this article, for the first time, we report the direct visualization of the Papez circuit with 7-Tesla super-resolution magnetic resonance tractography. Two healthy, young male subjects (aged 30 and 35 years) were recruited as volunteers following the guidelines of the institutional review board (IRB). Track density imaging (TDI) generation with track tracing was performed using MRtrix software package. With these tools, we were able to visualize the entire Papez circuit. We believe this is the first study to visualize the complete loop of the Papez circuit, including the perforant path (PP), thalamocortical fibers of the anterior nucleus (AN), and mammillothalamic tract (MTT), which were hitherto difficult to visualize by conventional imaging techniques.
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