ReviewFrontiers in neuroanatomy2019
Papez's Forgotten Tract: 80 Years of Unreconciled Findings Concerning the Thalamocingulate Tract.
Review in Frontiers in neuroanatomy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Microsurgical resection of gliomas of the cingulate gyrus: a systematic review and meta-analysis.Neurosurgical review · 2023Pooled it
- A co-alteration parceling of the cingulate cortex.Brain structure & function · 2022Pooled it
- Nucleus-level thalamic organization anchors multimodal signatures of thalamocortical maturation.bioRxiv : the preprint server for biology · 2026Article
- Diffusion tensor imaging analysis of aged dogs with and without canine cognitive dysfunction.BMC veterinary research · 2025Article
- Functional Recovery of Episodic Memory After Bilateral Fornix Infarction: A Longitudinal Tractography Case Report.Cureus · 2025Article
- Absence seizures: Update on signaling mechanisms and networks.Epilepsia open · 2025Article
- Comparison of structural connectomes for modeling deep brain stimulation pathway activation.NeuroImage · 2025Article
- White Matter Dissection: Lessons from the United Kingdom National Neuroanatomy Undergraduate Competition 2023.Asian journal of neurosurgery · 2025Article
- Altered Effective Connectivity During Threat Anticipation in Individuals With Alcohol Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection.Nature communications · 2025Article
- The cingulum: anatomy, connectivity and what goes beyond.Brain communications · 2025Review
- Case report: First experience with stimulating anterior thalamic nuclei in pharmacoresistant epilepsy in Kazakhstan.Frontiers in human neuroscience · 2024Article
- Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder.Frontiers in psychiatry · 2024Review
- Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along-tract analysis.The European journal of neuroscience · 2022Article
- Effective connectivity and criminal sentencing decisions: dynamic causal models in laypersons and legal experts.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- MRI volumetric changes in hippocampal subfields in psychosis: a protocol for a systematic review and meta-analysis.Systematic reviews · 2022Article
- Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis.Frontiers in psychiatry · 2022Review
- Surgical techniques and function outcome for cingulate gyrus glioma, how we do it.Frontiers in oncology · 2022Article
- Abnormal White Matter Microstructure in the Limbic System Is Associated With Tuberous Sclerosis Complex-Associated Neuropsychiatric Disorders.Frontiers in neurology · 2022Article
- Probabilistic mapping of thalamic nuclei and thalamocortical functional connectivity in idiopathic generalised epilepsy.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The thalamocingulate tract is a key component of the Papez circuit that connects the anterior thalamic nucleus (ATN) to the cingulum bundle. While the other white matter connections, consisting of the fornix, cingulum bundle and mammillothalamic tract, were well defined in Papez's original 1937 paper, the anatomy of the thalamocingulate pathway was mentioned only in passing. Subsequent research has been unable to clarify the precise anatomical trajectory of this tract. In particular, the site of thalamocingulate tract interactions with the cingulum bundle have been inconsistently reported. This review aims to synthesize research on this least studied component of the Papez circuit. A systemic approach to reviewing historical anatomical dissection and neuronal tracing studies as well as contemporary diffusion magnetic resonance imaging studies of the thalamocingulate tract was undertaken across species. We found that although inconsistent, prior research broadly encompasses two differing descriptions of how the ATN interfaces with the cingulum after passing laterally through the anterior limb of the internal capsule. The first group of studies show that the pathway turns medially and rostrally and passes to the anterior cingulate region (Brodmann areas 24, 33, and 32) only. A second group suggests that the thalamocingulate tract interfaces with both the anterior and posterior cingulate (Brodmann areas 23 and 31) and retrosplenial region (Brodmann area 29). We discuss potential reasons for these discrepancies such as altering methodologies and species differences. We also discuss how these inconsistencies may be resolved in further research with refinements of terminology for the cingulate cortex and the thalamocingulate tract. Understanding the precise anatomical course of the last remaining unresolved final white matter tract in the Papez circuit may facilitate accurate investigation of the role of the complete Papez circuit in emotion and memory.
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Registered trials
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