ArticleJournal of Korean medical science2019
Frameless Fractionated Gamma Knife Radiosurgery with ICON™ for Large Metastatic Brain Tumors.
Article in Journal of Korean medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Outcome of three-fraction gamma knife radiosurgery for brain metastases according to fractionation scheme: preliminary results.Journal of neuro-oncology · 2019Trial
- Article
- Combined Surgical Strategy for Large Cystic Brain Metastases: A Case Series of Fractionated Stereotactic Radiotherapy With Cyst Drainage.Brain tumor research and treatment · 2026Article
- Fractionated Gamma Knife Radiosurgery as a Primary Treatment for Large Brain Metastases.Journal of Korean medical science · 2025Article
- Two-Day Fraction Gamma Knife Radiosurgery for Large Brain Metastasis.Journal of Korean Neurosurgical Society · 2024Article
- A 3-month survival model after Gamma Knife surgery in patients with brain metastasis from lung cancer with Karnofsky performance status ≤ 70.Scientific reports · 2023Article
- Fractionated versus staged gamma knife radiosurgery for mid-to-large brain metastases: a propensity score-matched analysis.Journal of neuro-oncology · 2023Article
- Let's make size not matter: tumor control and toxicity outcomes of hypofractionated Gamma Knife radiosurgery for large brain metastases.Journal of neuro-oncology · 2023Article
- Optimal mask fixation method for frameless radiosurgery with Leksell Gamma Knife IconJournal of applied clinical medical physics · 2023Article
- Fractionated Gamma Knife radiosurgery after cyst aspiration for large cystic brain metastases: case series and literature review.Neurosurgical review · 2022Review
- Retrospective Analysis of Treatment Workflow in Frame-Based and Frameless Gamma Knife Radiosurgery.Cureus · 2022Article
- Navigation of frameless fixation for gamma knife radiosurgery using fixed augmented reality.Scientific reports · 2022Article
- Dose-staged Gamma Knife radiosurgery for meningiomas: A retrospective study in a single center.Frontiers in neurology · 2022Article
- Progressive Vestibular Schwannoma following Subtotal or Near-Total Resection: Dose-Escalated versus Standard-Dose Salvage Stereotactic Radiosurgery.Journal of neurological surgery. Part B, Skull base · 2021Article
- Hypofractionated frameless gamma knife radiosurgery for large metastatic brain tumors.Clinical & experimental metastasis · 2021Article
- Dosimetric comparison of Gamma Knife® IconJournal of radiosurgery and SBRT · 2021Article
- Intracranial motion during frameless Gamma-Knife stereotactic radiosurgery.Journal of radiosurgery and SBRT · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, a new generation of gamma knife radiosurgery (GKRS) equipped with a frameless immobilization system has encouraged the use of fractionated GKRS as an increasingly favorable treatment option. We investigated the preliminary outcome of efficacy and toxicity associated with frameless fractionated gamma knife radiosurgery (FF GKRS) for the treatment of large metastatic brain tumors.
methodsFifteen patients with 17 lesions were treated using FF GKRS and included in this study, because of the large tumor size of more than 10 cm
resultsThe mean duration of clinical follow-up was 12 months (range, 4-24), and the local control rate was 100%. Tumor volume decreased in 13 lesions (76.5%), and remained stable in 4 lesions (23.5%). One patient was classified as new lesion development because of the occurrence of leptomeningeal seeding regardless of the tumor volume change. Compared with the initial volume at the time of FF GKRS, tumor volume change at the last follow-up was 62.32% ± 29.80%. Cumulative survival rate at 12 months was 93.3% ± 6.4%. One patient died during the follow-up period because of the progression of the primary disease. No patient showed radiation necrosis on the follow-up images.
conclusionDaily FF GKRS by gamma knife ICON™ revealed satisfactory tumor control rate and low morbidity, despite the short follow-up period. Further prospective studies and a longer follow-up of a large cohort of patients diagnosed with brain metastases are required to elucidate the effect of FF GKRS in brain metastases.
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