Evidence map›Paper›PMID 30833803›Full record

ArticleWorld journal of gastroenterology2019

Women on the liver transplantation waitlist are at increased risk of hospitalization compared to men.

Jessica B Rubin, Marie Sinclair, Robert S Rahimi, Elliot B Tapper, Jennifer C Lai

Abstract readComparative Study
In one paragraph

Article in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Systematic Sex-Based Inequity in the MELD Score-Based Allocation System for Liver Transplantation in Germany.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Hospitalized Women With Cirrhosis Have More Nonhepatic Comorbidities and Associated Complications Than Men.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2020
    Article
  8. Article
  9. Women who undergo liver transplant have longer length of stay post-transplant compared with men.Liver international : official journal of the International Association for the Study of the Liver · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jessica B RubinDivision of Gastroenterology and Hepatology, Department of Medicine, University of California-San Francisco, San Francisco, CA 94143 United States.
Marie SinclairDepartment of Gastroenterology and Hepatology, Austin Health, Heidelberg 3084, Victoria, Australia.
Robert S RahimiDivision of Hepatology, Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX 75346, United States.
Elliot B TapperDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI 48109, United States.
Jennifer C LaiDivision of Gastroenterology and Hepatology, Department of Medicine, University of California-San Francisco, San Francisco, CA 94143 United States. jennifer.lai@ucsf.edu.

Funding

NRSA Hepatology Training GrantT32DK060414 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mandana Khalili, JACQUELYN J. MAHER · 2002 to 2026
$6.8M
NIDDK NIH HHS T32 DK060414
6 · The paper itself

Abstract

backgroundHospital admissions are common among patients with cirrhosis, but patient factors associated with hospitalization have not been well characterized. Given recent data suggesting increased liver transplant waitlist dropout among women, we hypothesized that women on the liver transplant waitlist would have increased rates of hospitalization compared with men.

aimTo evaluate the role of gender on risk of hospitalization for patients on the liver transplant waitlist, in order to help explain gender disparities in waitlist outcomes.

methodsPatients listed for liver transplant at a single center in the United States were prospectively enrolled in the Functional Assessment in Liver Transplantation Study. Patients included in this retrospective analysis included those enrolled between March 2012 and December 2014 with at least 12 mo of follow up and without hepatocellular carcinoma. The primary and secondary outcomes were hospitalization and total inpatient days within 12 mo, respectively. Logistic and negative binomial regression associated baseline factors with outcomes.

resultsOf the 392 patients, 41% were female, with median (interquartile range) age 58 years (52-63) and model for end- stage liver disease 18 (15-22). Within 12 mo, 186 (47%) patients were hospitalized ≥ 1 time; 48% were readmitted, with a median of 8 (4-15) inpatient days. More women than men were hospitalized (54%

conclusionWomen with cirrhosis on the liver transplant waitlist have more hospitalizations and inpatient days in one year compared with men, suggesting that the experience of cirrhosis differs between men and women, despite similar baseline illness severity. Future studies should explore gender-specific vulnerabilities to help explain waitlist disparities.

Indexed as

Liver TransplantationWaiting ListsEnd Stage Liver DiseaseFemaleHospitalizationHumansLiver CirrhosisMaleMiddle AgedProspective StudiesRetrospective StudiesSeverity of Illness IndexSex FactorsTissue and Organ ProcurementUnited StatesCirrhosisGenderHospitalizationLiver transplantation waitlistReadmissionWomen

Identifiers

PMID30833803
PMCPMC6397730

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.