Evidence map›Paper›PMID 30833791›Full record

ArticleNature immunology2019

SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection.

Yan Lu, Ming-Chao Zhong, Jin Qian, Virginie Calderon, Mayra Cruz Tleugabulova, Thierry Mallevaey, André Veillette

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
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  5. MAIT cells: Conserved watchers on the wall.The Journal of experimental medicine · 2025
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  13. Bacteroides ovatus-mediated CD27Cellular & molecular immunology · 2022
    Article
  14. The impact of the gut microbiota on T cell ontogeny in the thymus.Cellular and molecular life sciences : CMLS · 2022
    Review
  15. Immune Checkpoint Receptors Signaling in T Cells.International journal of molecular sciences · 2022
    Review
  16. Review
  17. Development of αβ T Cells with Innate Functions.Advances in experimental medicine and biology · 2022
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yan LuLaboratory of Molecular Oncology, Institut de recherches cliniques de Montréal, Montréal, Québec, Canada.ORCID http://orcid.org/0000-0002-5893-6114
Ming-Chao ZhongLaboratory of Molecular Oncology, Institut de recherches cliniques de Montréal, Montréal, Québec, Canada.
Jin QianLaboratory of Molecular Oncology, Institut de recherches cliniques de Montréal, Montréal, Québec, Canada.
Virginie CalderonBioinformatics Core Facility, Institut de recherches cliniques de Montréal, Montréal, Québec, Canada.
Mayra Cruz TleugabulovaDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Thierry MallevaeyDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
André VeilletteLaboratory of Molecular Oncology, Institut de recherches cliniques de Montréal, Montréal, Québec, Canada. andre.veillette@ircm.qc.ca.ORCID http://orcid.org/0000-0003-1159-4345
Montreal Clinical Research Institute · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invariant natural killer T cells (iNKT cells) develop through an incompletely understood process that requires positive selection by CD4

Indexed as

AnimalsCell ProliferationCell SurvivalCostimulatory and Inhibitory T-Cell ReceptorsHumansMiceMice, KnockoutNatural Killer T-CellsProtein Tyrosine Phosphatase, Non-Receptor Type 6Proto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-fynReceptors, Antigen, T-CellSignaling Lymphocytic Activation Molecule Associated ProteinSignaling Lymphocytic Activation Molecule FamilySignal TransductionCostimulatory and Inhibitory T-Cell ReceptorsProtein Tyrosine Phosphatase, Non-Receptor Type 6Proto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-fynPtpn6 protein, mouseReceptors, Antigen, T-CellSh2d1a protein, mouseSignaling Lymphocytic Activation Molecule Associated ProteinSignaling Lymphocytic Activation Molecule FamilySLAMF6 protein, humanSlamf6 protein, mouse

Identifiers

PMID30833791
OpenAlexW2918271856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.