ArticleNature microbiology2019
Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity.
Abstract read
In one paragraph
Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Effects of Probiotics on Preterm Infant Gut Microbiota Across Populations: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2024Pooled it
- Stable serum peptidoglycan fragment levels do not support leaky gut in the acute phase or at one month following "mild" traumatic brain injury: A preliminary study.Brain, behavior, & immunity - health · 2026Article
- The pathogenicity and future treatment strategies ofFrontiers in cellular and infection microbiology · 2026Review
- Gut dysbiosis in difficult-to-treat rheumatoid arthritis: hypothesized microbial endotypes, persistent inflammation, and pharmacological treatment resistance.Frontiers in pharmacology · 2026Review
- Article
- Microbial threads in the tapestry of rheumatoid arthritis.The Journal of clinical investigation · 2025Review
- Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that protects the host gut.Nature communications · 2025Article
- Synthetic High-Throughput Microarrays of Peptidoglycan Fragments as a Novel Sero-Diagnostic Tool for Patient Antibody Profiling.Angewandte Chemie (International ed. in English) · 2025Article
- A software tool and strategy for peptidoglycomics, the high-resolution analysis of bacterial peptidoglycans via LC-MS/MS.Communications chemistry · 2025Article
- Monocyte uptake of polymeric peptidoglycan is bimodal and governed by complement C3 and C4 opsonins.JCI insight · 2024Article
- Activation of NOD1 on tumor-associated macrophages augments CD8Science advances · 2024Article
- Re-evaluation of dietary interventions in rheumatoid arthritis: can we improve patient conversations around food choices?Rheumatology international · 2024Review
- Tissue-resident bacteria in metabolic diseases: emerging evidence and challenges.Nature metabolism · 2024Review
- Noninvasive Analysis of Peptidoglycan from Living Animals.Bioconjugate chemistry · 2024Article
- Peptidoglycan in osteoarthritis synovial tissue is associated with joint inflammation.Arthritis research & therapy · 2024Article
- Article
- NOD1: a metabolic modulator.Frontiers in endocrinology · 2024Review
- Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis.Nature cell biology · 2023Article
- Microbiota as the unifying factor behind the hallmarks of cancer.Journal of cancer research and clinical oncology · 2023Review
- Immunogenic molecules associated with gut bacterial cell walls: chemical structures, immune-modulating functions, and mechanisms.Protein & cell · 2023Review
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 4 countries.
Zhenxing Huang *Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.
Jianhe Wang *Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.
Xiaoli Xu *Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.
Haishan WangInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.ORCID http://orcid.org/0000-0002-7959-7377
Yuan QiaoInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.
Wern Cui ChuInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.
Shengli XuBioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore.
Louis ChaiDivision of Infectious Diseases, University Medicine Cluster, National University Health System, Singapore, Singapore.
Fabien CottierSingapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
Norman PavelkaSingapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.ORCID http://orcid.org/0000-0003-4542-9970
Marije OostingDepartment of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.
Leo A B JoostenDepartment of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0001-6166-9830
Mihai NeteaDepartment of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0003-2421-6052
Carol Yee Leng NgClinical Immunology Laboratory, Tan Tock Seng Hospital, Singapore, Singapore.
Khai Pang LeongDepartment of Rheumatology, Allergy and Immunology Laboratory, Tan Tock Seng Hospital, Singapore, Singapore.
Parag KunduLee Kong Chian School of Medicine, Nanyang Technology University, Singapore, Singapore.
Kong-Peng LamBioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore.
Sven PetterssonLee Kong Chian School of Medicine, Nanyang Technology University, Singapore, Singapore.
Yue WangInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore. mcbwangy@imcb.a-star.edu.sg.ORCID http://orcid.org/0000-0002-1211-2822
Agency for Science, Technology and Research · SGRadboud University Nijmegen · NLNanyang Technological University · SGTan Tock Seng Hospital · SGNational University of Singapore · SGSouth China Agricultural University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human microbiota provides tonic signals that calibrate the host immune response
Indexed as
MicrobiotaAnimalsAntibodies, NeutralizingArthritisAutoimmunityBacteriaEncephalomyelitisFemaleHumansMaleMiceMice, Inbred BALB CMice, Inbred DBANod2 Signaling Adaptor ProteinPeptidoglycanAntibodies, NeutralizingNod2 protein, mouseNod2 Signaling Adaptor ProteinPeptidoglycan
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.