ArticleNature neuroscience2019
Rapid, biphasic CRF neuronal responses encode positive and negative valence.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed, 159 citations in OpenAlex.
- Hypothalamic POMC Neurons Gate the Fear-Feeding Trade-Off.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Hypothalamic representation of aggressiveness across mouse strains.Nature communications · 2026Article
- Maternal Stress During Pregnancy Induces Higher Anxiety-Like Behavior in Male Mice Offspring Under Acute Stress by Upregulating CRF/CRFR1 and Driving Time-Specific Activation of the MHb-IPN Circuit.Neuroscience bulletin · 2026Article
- A Hypothalamic Inhibitory Circuit Encoding the Scalability of Stress Responses.bioRxiv : the preprint server for biology · 2026Article
- Adaptation of hypothalamic CRH neuron responses to stress and pup cues during motherhood.Communications biology · 2026Article
- Medial prefrontal cortex neurons integrate amygdala and hypothalamic oxytocin signals to mediate stress-induced social alterations.Communications biology · 2026Article
- Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive-Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39-PTH2R Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Appetitive maternal behavior in mice is resistant to perinatal chronic variable stress and perinatal chronic corticosterone treatment.Hormones and behavior · 2026Article
- Prefrontal corticotropin-releasing factor promotes resilience to social stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Ultradian rhythms of CRHProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Single-cell genomics meets systems neuroscience: Insights from mapping the brain circuitry of stress.Journal of neuroendocrinology · 2025Review
- The paraventricular nucleus of the hypothalamus: a key node in the control of behavioural states.The Journal of physiology · 2025Review
- Article
- Direct Modulation of CRH Nerve Terminal Function by Noradrenaline and Corticosterone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism.Frontiers in molecular neuroscience · 2025Review
- Bidirectional valence coding in amygdala intercalated clusters: A neural substrate for the opponent-process theory of motivation.Neuroscience research · 2024Article
- Dynamic changes of media prefrontal cortex astrocytic activity in response to negative stimuli in male mice.Neurobiology of stress · 2024Article
- Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins.Journal of endocrinological investigation · 2024Review
- Divergent neural nodes are species- and hormone-dependent in the brood parasitic brain.Genes, brain, and behavior · 2024Article
- Dopaminergic Neurons in Zona Incerta Drives Appetitive Self-Grooming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Corticotropin-releasing factor (CRF) that is released from the paraventricular nucleus (PVN) of the hypothalamus is essential for mediating stress response by activating the hypothalamic-pituitary-adrenal axis. CRF-releasing PVN neurons receive inputs from multiple brain regions that convey stressful events, but their neuronal dynamics on the timescale of behavior remain unknown. Here, our recordings of PVN CRF neuronal activity in freely behaving mice revealed that CRF neurons are activated immediately by a range of aversive stimuli. By contrast, CRF neuronal activity starts to drop within a second of exposure to appetitive stimuli. Optogenetic activation or inhibition of PVN CRF neurons was sufficient to induce a conditioned place aversion or preference, respectively. Furthermore, conditioned place aversion or preference induced by natural stimuli was significantly decreased by manipulating PVN CRF neuronal activity. Together, these findings suggest that the rapid, biphasic responses of PVN CRF neurons encode the positive and negative valences of stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.