Evidence map›Paper›PMID 30833588›Full record

ArticleScientific reports2019

Dynamic Imaging of Glucose and Lactate Metabolism by

Jeffrey R Brender, Shun Kishimoto, Hellmut Merkle, Galen Reed, Ralph E Hurd, Albert P Chen, Jan Henrik Ardenkjaer-Larsen, Jeeva Munasinghe, Keita Saito, Tomohiro Seki and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
5.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Hyperpolarized [U-ACS chemical biology · 2026
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  4. Article
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  6. Review
  7. Article
  8. [Research Progress in Applying HyperpolarizedSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Review
  9. In vivo Metabolic Sensing of Hyperpolarized [1-Angewandte Chemie (International ed. in English) · 2024
    Article
  10. Article
  11. New Horizons in HyperpolarizedMolecular imaging and biology · 2024
    Article
  12. Article
  13. Isoflurane titration improves detection of hippocampal lactate byImaging neuroscience (Cambridge, Mass.) · 2024
    Article
  14. Initial feasibility and challenges of hyperpolarizedMagnetic resonance in medicine · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Hyperpolarized δ-[1-Scientific reports · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 3 countries.

Jeffrey R BrenderCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0001-7487-6169
Shun KishimotoCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Hellmut MerkleNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Galen ReedGeneral Electric Healthcare, Toronto, Canada.
Ralph E HurdGeneral Electric Healthcare, Toronto, Canada.
Albert P ChenGeneral Electric Healthcare, Toronto, Canada.
Jan Henrik Ardenkjaer-LarsenGeneral Electric Healthcare, Toronto, Canada.
Jeeva MunasingheNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Keita SaitoCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Tomohiro SekiCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Nobu OshimaCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Kazutoshi YamamotoCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Peter L ChoykeCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
James MitchellCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Murali C KrishnaCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. cherukum@mail.nih.gov.
National Institutes of Health · USGeneral Electric (Canada) · CA

Funding

Overhauser Enhanced Magnetic Resonance Imaging (OMRI)ZIABC010477 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHERUKURI, MURALI · 2009 to 2025
$16.1M
6 · The paper itself

Abstract

Metabolic reprogramming is one of the defining features of cancer and abnormal metabolism is associated with many other pathologies. Molecular imaging techniques capable of detecting such changes have become essential for cancer diagnosis, treatment planning, and surveillance. In particular,

Indexed as

Fluorodeoxyglucose F18GlucoseLactic AcidMagnetic Resonance SpectroscopyPositron-Emission TomographyFluorodeoxyglucose F18GlucoseLactic Acid

Identifiers

PMID30833588
PMCPMC6399318
OpenAlexW2918344699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.