ArticleNature communications2019
The Caspase-3 homolog DrICE regulates endocytic trafficking during Drosophila tracheal morphogenesis.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
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- The roles of jim lovell and uninflatable in different endopolyploid larval tissues of Drosophila melanogaster.PloS one · 2020Article
- Salvador-Warts-Hippo pathway regulates sensory organ development via caspase-dependent nonapoptotic signaling.Cell death & disease · 2019Article
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Although well known for its role in apoptosis, the executioner caspase DrICE has a non-apoptotic function that is required for elongation of the epithelial tubes of the Drosophila tracheal system. Here, we show that DrICE acts downstream of the Hippo Network to regulate endocytic trafficking of at least four cell polarity, cell junction and apical extracellular matrix proteins involved in tracheal tube size control: Crumbs, Uninflatable, Kune-Kune and Serpentine. We further show that tracheal cells are competent to undergo apoptosis, even though developmentally-regulated DrICE function rarely kills tracheal cells. Our results reveal a developmental role for caspases, a pool of DrICE that co-localizes with Clathrin, and a mechanism by which the Hippo Network controls endocytic trafficking. Given reports of in vitro regulation of endocytosis by mammalian caspases during apoptosis, we propose that caspase-mediated regulation of endocytic trafficking is an evolutionarily conserved function of caspases that can be deployed during morphogenesis.
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Registered trials
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