ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Neuronal Adaptation Reveals a Suboptimal Decoding of Orientation Tuned Populations in the Mouse Visual Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 42 citations in OpenAlex.
- A standardized and reproducible behavioral framework to elicit multiple aspects of visual spatial attention in mice.Cell reports methods · 2026Article
- The curriculum effect in visual learning: The role of readout dimensionality.PLoS computational biology · 2026Article
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- Behavioral state and stimulus strength regulate the role of somatostatin interneurons in stabilizing network activity.Cell reports · 2025Article
- Adaptation with Naturalistic Textures in Macaque V1 and V2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Adaptation shapes the representational geometry in mouse V1 to efficiently encode the environment.bioRxiv : the preprint server for biology · 2025Article
- Recent Visual Experience Reshapes V4 Neuronal Activity and Improves Perceptual Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Network influence determines the impact of cortical ensembles on stimulus detection.bioRxiv : the preprint server for biology · 2024Article
- Stimulus-dependent differences in cortical versus subcortical contributions to visual detection in mice.Current biology : CB · 2024Article
- Mammals Achieve Common Neural Coverage of Visual Scenes Using Distinct Sampling Behaviors.eNeuro · 2024Article
- A power law describes the magnitude of adaptation in neural populations of primary visual cortex.Nature communications · 2023Article
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- Input-specific synaptic depression shapes temporal integration in mouse visual cortex.bioRxiv : the preprint server for biology · 2023Article
- Feature representation under crowding in macaque V1 and V4 neuronal populations.Current biology : CB · 2022Article
- A general decoding strategy explains the relationship between behavior and correlated variability.eLife · 2022Article
- Brief Stimuli Cast a Persistent Long-Term Trace in Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits.Nature communications · 2022Article
- Dynamics of history-dependent perceptual judgment.Nature communications · 2021Article
- Probabilistic discrimination of relative stimulus features in mice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Mouse Higher Visual Areas Provide Both Distributed and Specialized Contributions to Visually Guided Behaviors.Current biology : CB · 2020Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Sensory information is encoded by populations of cortical neurons. Yet, it is unknown how this information is used for even simple perceptual choices such as discriminating orientation. To determine the computation underlying this perceptual choice, we took advantage of the robust visual adaptation in mouse primary visual cortex (V1). We first designed a stimulus paradigm in which we could vary the degree of neuronal adaptation measured in V1 during an orientation discrimination task. We then determined how adaptation affects task performance for mice of both sexes and tested which neuronal computations are most consistent with the behavioral results given the adapted population responses in V1. Despite increasing the reliability of the population representation of orientation among neurons, and improving the ability of a variety of optimal decoders to discriminate target from distractor orientations, adaptation increases animals' behavioral thresholds. Decoding the animals' choice from neuronal activity revealed that this unexpected effect on behavior could be explained by an overreliance of the perceptual choice circuit on target preferring neurons and a failure to appropriately discount the activity of neurons that prefer the distractor. Consistent with this all-positive computation, we find that animals' task performance is susceptible to subtle perturbations of distractor orientation and optogenetic suppression of neuronal activity in V1. This suggests that to solve this task the circuit has adopted a suboptimal and task-specific computation that discards important task-related information.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.