ArticleCold Spring Harbor molecular case studies2019
Base excision repair deficiency signatures implicate germline and somatic
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Article in Cold Spring Harbor molecular case studies, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Germline haploinsufficiency of MUTYH causes mutational signature SBS18 in multiple tumour types and specifically raises colorectal cancer risk.NPJ precision oncology · 2026Article
- Decoding Pancreatic Cancer Pain: From Tumor-Nerve Crosstalk to Targeted Analgesic Strategies.International journal of medical sciences · 2026Review
- Mono-allelic MUTYH mutation as the likely inherited etiology of hereditary breast cancer in a patient from a multi-cancer family- report of a family and literature review.BMC medical genomics · 2025Review
- Prevalence of germline variants in Brazilian pancreatic carcinoma patients.Scientific reports · 2024Article
- Exploring the Role of theGenes · 2024Article
- Pan-Cancer Interrogation ofJCO precision oncology · 2024Article
- Article
- Association of base excision repair pathway genesInternational journal of occupational medicine and environmental health · 2022Article
- Incident Cancer Risk and Signatures Among Older MUTYH Carriers: Analysis of Population-Based and Genomic Cohorts.Cancer prevention research (Philadelphia, Pa.) · 2022Article
- Concordance of hydrogen peroxide-induced 8-oxo-guanine patterns with two cancer mutation signatures of upper GI tract tumors.Science advances · 2022Article
- Mutational signatures are markers of drug sensitivity of cancer cells.Nature communications · 2022Article
- Breast cancer in the era of integrating "Omics" approaches.Oncogenesis · 2022Review
- MUTYH-associated tumor syndrome: The other face of MAP.Oncogene · 2022Review
- Whole-genome and transcriptome analysis of advanced adrenocortical cancer highlights multiple alterations affecting epigenome and DNA repair pathways.Cold Spring Harbor molecular case studies · 2022Article
- Single-cell analysis of somatic mutation burden in mammary epithelial cells of pathogenic BRCA1/2 mutation carriers.The Journal of clinical investigation · 2022Article
- Mapping the genomic diaspora of gastric cancer.Nature reviews. Cancer · 2022Review
- Comparison of somatic mutation landscapes in Chinese versus European breast cancer patients.HGG advances · 2022Article
- Classification of the canonical splice alterationCold Spring Harbor molecular case studies · 2022Article
- The base excision repair process: comparison between higher and lower eukaryotes.Cellular and molecular life sciences : CMLS · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 4 institutions in 2 countries.
My Linh ThibodeauDepartment of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada.ORCID 0000-0002-2600-1197
Eric Y ZhaoCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.ORCID 0000-0003-1277-6335
Caralyn ReisleCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Carolyn Ch'ngCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.ORCID 0000-0003-0323-4243
Hui-Li WongDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia V5Z 4E6, Canada.
Yaoqing ShenCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Martin R JonesCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Howard J LimDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia V5Z 4E6, Canada.
Sean YoungDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada.
Carol CreminHereditary Cancer Program, BC Cancer, Vancouver, British Columbia V5Z 1H5, Canada.
Erin PleasanceCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Wei ZhangCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Robert HoltDepartment of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada.
Peter EirewDepartment of Molecular Oncology, BC Cancer, Vancouver, British Columbia V5Z 1L3, Canada.
Joanna KarasinskaPancreas Centre BC, Vancouver, British Columbia V5Z 1L8, Canada.
Steve E KallogerPancreas Centre BC, Vancouver, British Columbia V5Z 1L8, Canada.
Greg TaylorCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Elisa MajounieCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Melika BonakdarCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Zusheng ZongCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Dustin BleileCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Readman ChiuCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Inanc BirolDepartment of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada.
Karen GelmonDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia V5Z 4E6, Canada.
Caroline LohrischDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia V5Z 4E6, Canada.
Karen L MungallCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Andrew J MungallCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.ORCID 0000-0002-0905-2742
Richard MooreCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Yussanne P MaCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Alexandra FokCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 4S6, Canada.
Stephen YipCancer Genetics and Genomics Laboratory, BC Cancer, Vancouver, British Columbia V5Z 4E6, Canada.
Aly KarsanDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada.
David HuntsmanDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada.
David F SchaefferDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada.
Janessa LaskinDepartment of Medical Oncology, BC Cancer, Vancouver, British Columbia V5Z 4E6, Canada.
Marco A MarraDepartment of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada.
Daniel J Renouf *Department of Medical Oncology, BC Cancer, Vancouver, British Columbia V5Z 4E6, Canada.
Steven J M Jones *Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada.
Kasmintan A Schrader *Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada.
Canada's Michael Smith Genome Sciences Centre · CABC Cancer Agency · CAUniversity of British Columbia · CAPancreas Centre (Canada) · CA
Funding
CIHR
Abstract
We report a case of early-onset pancreatic ductal adenocarcinoma in a patient harboring biallelic
Indexed as
MutationAge of OnsetBreast NeoplasmsCarcinoma, Pancreatic DuctalDNA GlycosylasesFemaleGerm-Line MutationHumansLoss of HeterozygosityMiddle AgedPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)DNA GlycosylasesKRAS protein, humanmutY adenine glycosylaseProto-Oncogene Proteins p21(ras)neoplasm of the breastneoplasm of the pancreaspancreatic adenocarcinoma
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.