Evidence map›Paper›PMID 30833344›Full record

ArticleEMBO reports2019

miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity.

James P Hewitson, Kunal M Shah, Najmeeyah Brown, Paul Grevitt, Sofia Hain, Katherine Newling, Tyson V Sharp, Paul M Kaye, Dimitris Lagos

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. miR-132-3p downregulatesThe Journal of international medical research · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Deciphering the Molecular Mechanisms of Chilling Tolerance inInternational journal of molecular sciences · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Journal of immunology (Baltimore, Md. : 1950) · 2020
    Article
  13. Mechanisms Underlying Dysregulation of miR-132 in Alzheimer's Disease.Biomedical journal of scientific & technical research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

James P HewitsonCentre for Immunology and Infection and York Biomedical Research Institute, Hull York Medical School and Department of Biology, University of York, York, UK.ORCID 0000-0002-3265-6763
Kunal M ShahCentre of Molecular Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University London, London, UK.
Najmeeyah BrownCentre for Immunology and Infection and York Biomedical Research Institute, Hull York Medical School and Department of Biology, University of York, York, UK.
Paul GrevittCentre of Molecular Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University London, London, UK.
Sofia HainCentre for Immunology and Infection and York Biomedical Research Institute, Hull York Medical School and Department of Biology, University of York, York, UK.
Katherine NewlingGenomics and Bioinformatics Laboratory, Bioscience Technology Facility, Department of Biology, University of York, York, UK.
Tyson V SharpCentre of Molecular Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University London, London, UK.ORCID 0000-0003-1861-7984
Paul M KayeCentre for Immunology and Infection and York Biomedical Research Institute, Hull York Medical School and Department of Biology, University of York, York, UK.ORCID 0000-0002-8796-4755
Dimitris LagosCentre for Immunology and Infection and York Biomedical Research Institute, Hull York Medical School and Department of Biology, University of York, York, UK dimitris.lagos@york.ac.uk.ORCID 0000-0003-0637-281X
University of York · GBQueen Mary University of London · GB

Funding

Medical Research Council G1000230Medical Research Council MR/L008505/1Medical Research Council MR/N009185/1
6 · The paper itself

Abstract

Determining the mechanisms that distinguish protective immunity from pathological chronic inflammation remains a fundamental challenge. miR-132 has been shown to play largely immunoregulatory roles in immunity; however, its role in CD4

Indexed as

Gene Expression RegulationRNA InterferenceAnimalsBinding SitesCD4-Positive T-LymphocytesCytokinesFemaleGene Expression ProfilingGene Regulatory NetworksHost-Pathogen InteractionsLymphocyte ActivationMiceMice, TransgenicMicroRNAsp300-CBP Transcription FactorsProtein BindingCytokinesMicroRNAsMIRN132 microRNA, mousep300-CBP Transcription FactorsRibosomal ProteinsTranscription Factor TFIIDLeishmaniamicroRNAmiR‐132ribosomal proteinsTh cells

Identifiers

PMID30833344
PMCPMC6446204
OpenAlexW2919515177

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.