Evidence map›Paper›PMID 30833338›Full record

ArticleInfection and immunity2019

Metabolites Involved in Immune Evasion by

Louise A Rollins-Smith, Antonio C Ruzzini, J Scott Fites, Laura K Reinert, Emily M Hall, Bryan A Joosse, Vishvaas I Ravikumar, Megan I Huebner, Audrey Aka, Miles H Kehs and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Amphibian (Journal of fungi (Basel, Switzerland) · 2025
    Article
  4. Exposure toPeerJ · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Amphibian infection tolerance to chytridiomycosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  9. Selection of an anti-pathogen skin microbiome following prophylaxis treatment in an amphibian model system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Immunological Aspects of Chytridiomycosis.Journal of fungi (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Louise A Rollins-SmithDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA louise.rollins-smith@vanderbilt.edu.
Antonio C RuzziniDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
J Scott FitesDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.
Laura K ReinertDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Emily M HallDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Bryan A JoosseDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.
Vishvaas I RavikumarDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Megan I HuebnerDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Audrey AkaDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Miles H KehsDivision of Natural and Computational Sciences, Gwynedd Mercy University, Gwynedd Valley, Pennsylvania, USA.
Bria M GillardDivision of Natural and Computational Sciences, Gwynedd Mercy University, Gwynedd Valley, Pennsylvania, USA.
Emily DoeDepartment of Chemistry, Villanova University, Villanova, Pennsylvania, USA.
Julia A TascaDepartment of Chemistry, Villanova University, Villanova, Pennsylvania, USA.
Thomas P UmileDivision of Natural and Computational Sciences, Gwynedd Mercy University, Gwynedd Valley, Pennsylvania, USA.
Jon ClardyDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
Kevin P C MinbioleDepartment of Chemistry, Villanova University, Villanova, Pennsylvania, USA.
Vanderbilt University · USVillanova University · USGwynedd Mercy University · USHarvard University · US

Funding

Chemical biology of bacterial symbiontsR01AT009874 · NCCIH · HARVARD MEDICAL SCHOOL · PI CLARDY, JON · 2017 to 2019
$1.2M
NCCIH NIH HHS R01 AT009874
6 · The paper itself

Abstract

Amphibians have been declining around the world for more than four decades. One recognized driver of these declines is the chytrid fungus

Indexed as

AmphibiansAnimalsChytridiomycotaHost-Pathogen InteractionsImmune EvasionMycosesPolyaminesSpermidinePolyaminesSpermidineamphibian declinesBatrachochytrium dendrobatidisdifluoromethylarginine (DFMA)difluoromethylornithine (DFMO)immunomodulationmethylthioadenosinepolyamineputrescinespermidinesplenocytes

Identifiers

PMID30833338
PMCPMC6479046
OpenAlexW2920313046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.