Evidence map›Paper›PMID 30833327›Full record

ArticleThe Journal of biological chemistry2019

Zebrafish olfactory receptors ORAs differentially detect bile acids and bile salts.

Xiaojing Cong, Qian Zheng, Wenwen Ren, Jean-Baptiste Chéron, Sébastien Fiorucci, Tieqiao Wen, Chunbo Zhang, Hongmeng Yu, Jérôme Golebiowski, Yiqun Yu

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
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  5. Frontiers in cell and developmental biology · 2025
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  7. Article
  8. Article
  9. Review
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  12. Article
  13. Article
  14. Article
  15. Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaojing CongUniversité Côte d'Azur, CNRS, Institut de Chimie de Nice UMR7272, Nice 06108 France.ORCID 0000-0002-5051-2392
Qian ZhengFrom the School of Life Sciences, Shanghai University, Shanghai 200444 China.
Wenwen RenInstitutes of Biomedical Sciences, Fudan University, Shanghai 200031 China, and.
Jean-Baptiste ChéronUniversité Côte d'Azur, CNRS, Institut de Chimie de Nice UMR7272, Nice 06108 France.
Sébastien FiorucciUniversité Côte d'Azur, CNRS, Institut de Chimie de Nice UMR7272, Nice 06108 France.ORCID 0000-0003-2245-0478
Tieqiao WenFrom the School of Life Sciences, Shanghai University, Shanghai 200444 China.
Chunbo ZhangDepartment of Biological and Chemical Sciences, Illinois Institute of Technology, Chicago, Illinois 60616.
Hongmeng YuDepartment of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University, Shanghai 200031 China, hongmengyush@fudan.edu.cn.
Jérôme GolebiowskiUniversité Côte d'Azur, CNRS, Institut de Chimie de Nice UMR7272, Nice 06108 France, jerome.golebiowski@unice.fr.ORCID 0000-0002-3675-1952
Yiqun YuFrom the School of Life Sciences, Shanghai University, Shanghai 200444 China, yiqun_yu@shu.edu.cn.

Funding

Characterization of Olfactory ReceptorsR15DC011650 · NIDCD · ILLINOIS INSTITUTE OF TECHNOLOGY · PI ZHANG, CHUNBO · 2011 to 2011
$439k
NIDCD NIH HHS R15 DC011650
6 · The paper itself

Abstract

The fish olfactory receptor ORA family is orthologous to the mammalian vomeronasal receptors type 1. It consists of six highly conserved chemosensory receptors expected to be essential for survival and communication. We deorphanized the zebrafish ORA family in a heterologous cell system. The six receptors responded specifically to lithocholic acid (LCA) and closely related C

Indexed as

Amino Acid SequenceAnimalsBile Acids and SaltsComputer SimulationLigandsMutagenesis, Site-DirectedReceptors, OdorantStructure-Activity RelationshipZebrafishZebrafish ProteinsBile Acids and SaltsLigandsReceptors, OdorantZebrafish Proteinsbehavioral assayfish ORAhomology modelingmolecular dockingmolecular dynamicsolfactory receptorreceptor structure–functionsite-directed mutagenesis

Identifiers

PMID30833327
PMCPMC6497948

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.