Evidence map›Paper›PMID 30833320›Full record

Observational studyBMJ open2019

Multimorbidity of cardiometabolic diseases: prevalence and risk for mortality from one million Chinese adults in a longitudinal cohort study.

Dudan Zhang, Xun Tang, Peng Shen, Yaqin Si, Xiaofei Liu, Zhe Xu, Jinguo Wu, Jingyi Zhang, Ping Lu, Hongbo Lin and 1 more

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05284162 (Effects of a Theory-guided Health Coaching Programme on Health Promoting Behaviours in Middle-Aged Adults With Cardiometabolic Risk), which is not on this map. Cited by 143 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 5 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05284162 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Effects of a Theory-guided Health Coaching Programme on Health Promoting Behaviours in Middle-Aged Adults With Cardiometabolic Risk: a Randomised Controlled Trial

TypeinterventionalSponsorChinese University of Hong KongRan2021 to 2023Enrolled202ConditionsCoaching, Cardiovascular Diseases, Metabolic DiseasesArmsHealth coaching
3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 5 syntheses or guidelines pooled it, 218 citations in OpenAlex.

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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Dudan Zhang *Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.ORCID 0000-0002-4596-1118
Xun Tang *Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.ORCID 0000-0002-6990-0168
Peng ShenYinzhou District Center for Disease Control and Prevention, Ningbo, China.
Yaqin SiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Xiaofei LiuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Zhe XuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Jinguo WuWonders Information Co., Ltd, Shanghai, China.
Jingyi ZhangWonders Information Co., Ltd, Shanghai, China.
Ping LuWonders Information Co., Ltd, Shanghai, China.
Hongbo LinYinzhou District Center for Disease Control and Prevention, Ningbo, China.
Pei GaoDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Peking University · CNWanfang Data (China) · CNNingbo Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe evolution of multimorbidity describes the continuum from a healthy status to the development of a single disease and further progression to multimorbidity with additional diseases. We investigated the evolution of cardiometabolic multimorbidity and risk for mortality in a Chinese population.

designLongitudinal cohort study using data from the CHinese Electronic health Records Research in Yinzhou (CHERRY) study, with 5.43 million person-years follow-up (median 5.16 years).

participantsData for 1 038 704 adults (total 22 750 deaths) were analysed. EXPOSURE: Cardiometabolic multimorbidity was defined as ever being diagnosed with two or more of three diseases: hypertension, diabetes and cardiovascular disease (CVD). PRIMARY AND SECONDARY OUTCOME MEASURES: Age-adjusted and sex-adjusted HRs were calculated for all-cause mortality.

resultsThe cardiometabolic disease status of 105 209 (10.1%) individuals changed during the follow-up. The prevalence of cardiometabolic multimorbidity increased from 2.41% (95% CI: 2.38% to 2.44%) to 5.94% (95% CI: 5.90% to 5.99%). Baseline multimorbidity status showed the HR (95% CI) was 1.37 (1.33 to 1.42) in those with one disease, 1.71 (1.64 to 1.79) in those with two diseases and 2.22 (2.00 to 2.46) in those with three diseases. The highest HRs were observed for CVD only (3.31, 95% CI: 3.05 to 3.59) or diabetes and CVD (3.12, 95% CI: 2.37 to 4.11). Those with hypertension only had the lowest HR (1.26, 95% CI: 1.22 to 1.30). Longitudinal data showed the HRs (95% CI) in patients with one, two and three diseases were 1.36 (1.32 to 1.41), 2.03 (1.96 to 2.10) and 2.16 (2.05 to 2.29), respectively.

conclusionsThe prevalence of cardiometabolic multimorbidity in a general Chinese population increased more than doubled over 5 years, indicating rapid evolution of cardiometabolic multimorbidity. A history of CVD dominates the risk for mortality. A complementary strategy for primary and secondary prevention of cardiometabolic diseases is needed in China.

Indexed as

MultimorbidityAdultAgedCardiovascular DiseasesChinaDiabetes MellitusFemaleHumansHypertensionLongitudinal StudiesMaleMiddle AgedPrevalenceYoung Adultcardiovascular diseasediabeteshypertensionlongitudinalmultimorbidity

Identifiers

PMID30833320
PMCPMC6443196
OpenAlexW2919938550

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.