Evidence map›Paper›PMID 30833303›Full record

ArticleMolecular systems biology2019

Path-seq identifies an essential mycolate remodeling program for mycobacterial host adaptation.

Eliza Jr Peterson, Rebeca Bailo, Alissa C Rothchild, Mario L Arrieta-Ortiz, Amardeep Kaur, Min Pan, Dat Mai, Abrar A Abidi, Charlotte Cooper, Alan Aderem and 2 more

Abstract read
In one paragraph

Article in Molecular systems biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Transcript-Capture sequencing enriches mRNA ofbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Predicting fitness inFrontiers in tuberculosis · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  19. MadR mediates acyl CoA-dependent regulation of mycolic acid desaturation in mycobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eliza Jr PetersonInstitute for Systems Biology, Seattle, WA, USA.ORCID 0000-0003-2934-5267
Rebeca BailoSchool of Biosciences and Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.ORCID 0000-0003-3580-1273
Alissa C RothchildCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.ORCID 0000-0001-7484-1193
Mario L Arrieta-OrtizInstitute for Systems Biology, Seattle, WA, USA.
Amardeep KaurInstitute for Systems Biology, Seattle, WA, USA.
Min PanInstitute for Systems Biology, Seattle, WA, USA.
Dat MaiCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Abrar A AbidiInstitute for Systems Biology, Seattle, WA, USA.
Charlotte CooperSchool of Biosciences and Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.
Alan AderemCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Apoorva BhattSchool of Biosciences and Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK a.bhatt@bham.ac.uk nitin.baliga@systemsbiology.org.ORCID 0000-0002-6655-1636
Nitin S BaligaInstitute for Systems Biology, Seattle, WA, USA a.bhatt@bham.ac.uk nitin.baliga@systemsbiology.org.ORCID 0000-0001-9157-5974

Funding

Technology CoreU19AI135976 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI SHERMAN, DAVID R · 2018 to 2022
$17.0M
A systems analysis of drug tolerance in Mycobacterium tuberculosisR01AI128215 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI Nitin S Baliga · 2017 to 2026
$8.8M
Medical Research Council MR/K00042X/1NIAID NIH HHS R01 AI128215NIAID NIH HHS U19 AI135976
6 · The paper itself

Abstract

The success of

Indexed as

Gene Regulatory NetworksHost-Pathogen InteractionsAdaptation, PhysiologicalAnimalsAntigens, BacterialBacterial ProteinsCell WallMacrophagesMiceMycobacterium tuberculosisMycolic AcidsSystems BiologyTuberculosisAntigens, BacterialBacterial ProteinsdesA1 protein, Mycobacterium tuberculosisMycolic Acidsgene regulatory networkshost–pathogen interactionsMycobacterium tuberculosisPath‐seqsystems biology

Identifiers

PMID30833303
PMCPMC6398593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.