Evidence map›Paper›PMID 30833291›Full record

ArticleThe EMBO journal2019

Hfq-dependent mRNA unfolding promotes sRNA-based inhibition of translation.

Mirthe Hoekzema, Cédric Romilly, Erik Holmqvist, E Gerhart H Wagner

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 59 citations in OpenAlex.

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  10. TheFrontiers in cellular and infection microbiology · 2025
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  11. ThebioRxiv : the preprint server for biology · 2024
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  14. Enhancing the Efficacy of Chloramphenicol Therapy forAntibiotics (Basel, Switzerland) · 2024
    Article
  15. Review
  16. Molecular responses during bacterial filamentation reveal inhibition methods of drug-resistant bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mirthe HoekzemaDepartment of Cell and Molecular Biology, Biomedical Center, Uppsala University, Uppsala, Sweden.ORCID 0000-0001-7808-7781
Cédric RomillyDepartment of Cell and Molecular Biology, Biomedical Center, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-2129-6667
Erik HolmqvistDepartment of Cell and Molecular Biology, Biomedical Center, Uppsala University, Uppsala, Sweden.ORCID 0000-0001-7834-1487
E Gerhart H WagnerDepartment of Cell and Molecular Biology, Biomedical Center, Uppsala University, Uppsala, Sweden gerhart.wagner@icm.uu.se.ORCID 0000-0003-2771-0486
Uppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small RNAs post-transcriptionally regulate many processes in bacteria. Base-pairing of sRNAs near ribosome-binding sites in mRNAs inhibits translation, often requiring the RNA chaperone Hfq. In the canonical model, Hfq simultaneously binds sRNAs and mRNA targets to accelerate pairing. Here, we show that the

Indexed as

Gene Expression Regulation, BacterialProtein BiosynthesisRNA FoldingEscherichia coliEscherichia coli ProteinsHost Factor 1 ProteinRibosomesRNA, BacterialRNA, MessengerRNA, Small UntranslatedEscherichia coli ProteinsHfq protein, E coliHost Factor 1 ProteinRNA, BacterialRNA, MessengerRNA, Small UntranslatedbiofilmHfqpost‐transcriptional regulationRNA structuresRNA

Identifiers

PMID30833291
PMCPMC6443205
OpenAlexW2792946775

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.